超声微泡造影剂在心血管疾病基因治疗中的应用

Application of ultrasound microbubble contrast agent in gene therapy of cardiovascular disease

基因治疗心血管疾病成为研究的热点及方向,但由于担心病毒载体的安全性以及非病毒载体的低效性,基因治疗的发展缓慢。而超声微泡造影剂可作为一种新型的基因转染载体,为目前处于困境中的基因治疗带来了新的曙光,本文就超声微泡造影剂在心血管疾病基因治疗中的应用作一综述。

Gene therapy of cardiovascular disease has become investigative hot spot and direction. But because of the safety of viral vectors and poor efficiency of non-viral vectors, gene therapy develops slowly. Ultrasound microbubble contrast agents are new gene transfection vector, and they bring a new light into gene therapy that occupying dilemma. This review describes the application of ultrasound microbubble contrast agents in gene therapy of cardiovascular disease.