新型螺环树状化合物的合成

Synthesis of Novel Spiro-dendrimer

利用环己二酮单腙芳构化反应,得到9H,9H,11H,11H,12H,12H-六氢化苯并[9,10]-(1H,1H,3H,3H,4H,4H,5H,5H,7H,7H,8H,8H-十二氢)菲-2,6,10-三酮腙,然后与季戊四醇反应,得到9H,9H,11H,11H,12H,12H-六氢化苯并[9,10]-(1H,1H,3H,3H,4H,4H,5H,5H,7H,7H,8H,8H-十二氢)菲-2,6,10-三酮缩三(2,2-二羟甲基-1,3-丙二醇),再与9-[4-(2,6-二硫杂环己基)苯基]-3-[4-(二甲酯基甲基)苯基]-2,4,8,10-四氧杂螺[5.5]十一烷反应,制成标题化合物.中间体和标题化合物经过IR,1HNMR,MS和元素分析表征.

A novel dendrimer-9H,9H, 11H, 11H, 12H, 12H-hexahydrobenzo[9,10 ] -1H, 1H,3H,3H,4H,4H, 5 H, 5 H, 7H, 7H, 8H, 8H-dodecahydrophenanthrene-2,6,10-trione ketal-tri- （ 4- （ 4- （ 3- （ 9- （ 4- （ 2,6-disulfo-cyclohexyl ） phenyl ） ） -2,4,8,10-tetra-oxa-spiro [ 5.5 ] undecyl ） ） phenyl-1,1 - （ 2,6-dioxa ） cyclohexanedimethanol was conveniently synthesized by the reaction of hexahydrobenzo[9,10 ] dodecahydrophenanthrene-2,6,10-trione ketal-tri-2,2-dihydromethyl-1,3 -propanediol with 4- （ 4- （ 3 - （ 9- （ 4- （ 2,6-disulfo-cyclohexyl ） phenyl ） ） -2, 4,8,10-tetra-oxa-spiro [ 5.5 ] undecyl） ） phenyl-1,1 - （ 2,6-dioxa ） cyclohexanedimethanol. Some reaction intermediates were prepared with common chemical reagent. Novel dendrimer and intermediates were identified via IR, ^1H NMR and MS spectra and elemental analysis.