齐墩果酸聚氰基丙烯酸正丁酯纳米囊在小鼠体内的肝靶向研究

Study on the liver targeting of oleanolic acid loaded polybutylcyanoacrylate nanocapsules in mice

目的:研究齐墩果酸聚氰基丙烯酸正丁酯纳米囊(OA-PBCA-NC)在小鼠体内的肝靶向性。方法:小鼠尾静脉注射OA-PBCA-NC试验组及齐墩果酸(OA)对照组,HPLC法测定小鼠心、肝、脾、肺、肾各脏器及血浆中OA的含量,比较两组体内分布特点,并进行靶向性评价。结果:秩和检验结果表明静脉注射OA-PBCA-NC试验组与OA对照组比较,其在肝脏的分布差异有显著性,OA-PBCA-NC静脉注射给药后能显著增加OA在肝脏的分布。试验组各肝靶向指标结果均优于对照组。结论:OA-PBCA-NC能增加OA的肝靶向性。

OBJECTIVE To study the liver targeting of oleanolic acid loaded polybutylcyanoacrylate nanocapsules（OA-PB- CA-NC） in mice. METHODS Injecting OA-PBCA-NC and oleanolic acid （OA） respectively to the tail vein of mice,the concentration of OA in the heart, liver, spleen, lung, kidney and blood were determined by HPLC. The distribution of OA in mice was studied. And the targeting property of OA was evaluated. RESULTS The results of rank sum test showed that the test group was evidently different from the control group, which could evidently increase the distribution of OA in liver. And the targeting index of the test group was more excellent than that of the control group. CONCLUSION The OA-PBCA-NC has good liver targeting property.