中药对衰老大鼠肝细胞超微结构的影响

The Effects of Herbs on Ultrastructure of Liver Cells in Aging Mice

目的研究制首乌、北沙参、紫丹参三味中药的保肝抗衰老作用。方法用D-半乳糖皮下注射,将2月龄大鼠制成衰老模型,用药组在造模的同时给予制首乌、北沙参、紫丹参3味药灌胃,40d后用电子显微镜观察各组大鼠肝细胞的形态学变化。结果衰老模型组肝细胞体积缩小,细胞核和细胞器损伤严重;中药治疗组肝细胞体积正常,细胞核和细胞器保持良好,接近正常对照组肝细胞的形态。结论制首乌、北沙参、紫丹参3味药联合应用能够改善肝细胞超微结构,抑制肝细胞的凋亡,具有保护肝细胞、抗衰老的功效。

Objective To study the effects of Polygonum multifiorum Thumb. , Adenophora paniculate and Radix Salviae Miltiorrhizae in protecting liver and anti - aging. Methods Aging models were made by hypodermic injection of D - galactose. The rats were given intragastrically with the decoction of Polygonum multifiorum Adenophora paniculate and Radix Salviae Miltiorrhizae at the same time. The morphologic changes in the liver cells were observed by transmission electronic microscope after 40 days. Resuits The volume of liver cells of aging model group shrinked, the cell nuclear and the cell organ were seriously damaged. The volume of liver cells of herbs cure group were normal, and the cell nuclear and the cell organ were conserved well, they were simllar in morphous to normal control group. Conclusion The combinated application of Polygonum multifiorum, Adenophora paniculate and Radix Salviae Miltiorrhizae plays the notable role in improving the ultrastructure of liver cells and delaying the process of senescence.