阿立哌唑与利培酮治疗女性精神分裂症对照研究

Comparative Study of Aripiprazole and Risperidone in the Treatment of Female Schizophrenias.

目的比较阿立哌唑与利培酮治疗女性精神分裂症患者的临床疗效和安全性。方法对60例符合CCM D-3诊断标准的精神分裂症病人随机分为两组,分别给予阿立哌唑和利培酮治疗8周。采用阳性症状和阴性症状量表(PANSS)评定临床疗效,副反应量表(TESS)评定副反应。结果治疗8周,阿立哌唑组和利培酮的显效率分别为73.33%和76.67%,差异无显著性(P>0.05),阿立哌唑组副反应(锥体外系、体重增加)的发生率明显低于利培酮组(P>0.05)。结论阿立哌唑治疗女性精神分裂症疗效好,起效快,不良反应少。

Objective To compare the efficacy and safety between aripirzole and risperidone in the treatment of female schizophrenia. Methods 60 case met the CCMD-3 criteria for schizophrenia were divided into two groups ramdomly, treated with Aripiprzole and riperidone respectively for 8 weeks, the Postitive and Negative syndomly Scale（PANSS） and Treament Emergent Symptom Scale （TESS） were used to assess the therapeutic efficacy and side effect respictively. Results Aripiprazole was as effective as Risperidone for the treatment of female sehiophrnia （P〉0.05）, there was no ohvious difference between two groups in significant improving rate （P〉0. 05）. But Aripiprazole produced fewer side effects, such as extrpyramidal symptom, gain weight than Risperidone. Conclusion Aripiprazole is an effective and safe drug in the treatment of female schizophrenias. Its side effects were fewer.