毛囊细胞混合物移植诱导裸鼠毛囊样结构形成

Hair follicle cell mixture forms hair follicle-like structures after subcutaneous implantation in nude mice

目的观察毛囊细胞复合物移植诱导裸鼠毛发再生和毛囊重建情况。方法采用裸鼠移植技术,将混合分离出来的毛囊细胞,包括毛囊毛乳头细胞、毛囊外根鞘细胞、毛囊真皮鞘细胞和毛囊真皮成纤维细胞等,移植到裸鼠皮下,观察毛囊形成情况。结果在裸鼠的皮肤切片中可以看到较为完整的毛囊结构形成。结论毛囊细胞混合物可以在体内诱导出毛囊样结构形成。

Objective To observe the hair follicle regeneration after subcutaneous implantation of hair follicle cell mixture in nude mice. Methods The hair papilla cells, dermal sheath cells, outer root sheath and fibroblasts of human scalp were mixed with the hair follicle epithelial cells and implanted subcutaneously in nude mice to observe the regeneration of the hair follicle. Results and Conclusion Formation of intact hair follicle-like structures was observed in the skin sections of the recipient nude mice, suggesting the feasibility of this approach for hair follicle regeneration in vivo.