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(3aS,6aR)-1,3-二苄基-六氢-1H-噻吩并[3,4-d]咪唑-2,4-二酮制备方法的改进 被引量：3

Improved method for the synthesis of(3aS,6aR)-1,3dipenzyl-hexahydro 1H-thienoimidazole-2,4-dione
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摘要 Thioacetamide is made from phosphorus pentasulfide and acetamide,which react with(3aS,6aR)-1,3-dibenzyl-hexahydro-1H-furo[3,4-d]imidazole-2,4-dione as sulfo-reagent to prepare(3aS,6aR)-1,3-dibenzyl-hexahydro-1H-thienoimidazole-2,4-dione in the same system,yield is 91.9%,material get easily and cost reduce by this method,which is suitable for industrial process. Thioacetamide is made from phosphorus pentasulfide and acetamide,which react with（3aS,6aR）-1,3-dibenzyl-hexahydro-1H-furo[3,4-d]imidazole-2,4-dione as sulfo-reagent to prepare（3aS,6aR）-1,3-dibenzyl-hexahydro-1H-thienoimidazole-2,4-dione in the same system,yield is 91.9%,material get easily and cost reduce by this method,which is suitable for industrial process.
作者 顾立新 王伟 蒋定强 黄忠印 沈润溥
机构地区 浙江医药股分有限公司新昌制药厂 绍兴文理学院化学化工学院
出处 《化学研究与应用》 CAS CSCD 北大核心 2007年第9期1056-1058,1062,共4页 Chemical Research and Application
关键词 (+)-生物素 (3aS 6aR)-1 3-二苄基-六氢-1H-噻吩并[3 4-d]咪唑-2 4-二酮 (3aS 6aR)-1 3-二苄基-六氢-1H-呋喃并[3 4-d]咪唑-2 4-二酮 硫代乙酰胺 五硫化二磷 乙酰胺 制备 （＋）-Biotin （3aS,6aR）-1,3-dibenzyl-hexahydro-1H-thienoimidazole-2,4-dione （3aS,6aR）-1,3-dibenzyl-hexahydro-1H-furoimidazole-2,4-dione thioacetamide phosphorus pentasulfide,acetamide,prepare
分类号 O626.23 [理学—有机化学]
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参考文献8

  • 1Goldberg M W,Sternbach L H.Synthesis of biotin,US 2489235[P]1949-11-22.
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二级参考文献4

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同被引文献30

  • 1潘林,孙建义.生物素的生理功能及其分子作用机制[J].中国饲料,2005(6):21-24. 被引量：19
  • 2马晓莉,吴敏媛,胡亚美,朱平,李志刚.巯嘌呤甲基转移酶基因多态性位点与酶活性的关系[J].中华肿瘤杂志,2006,28(6):456-459. 被引量：10
  • 3杨艳玲.生物素与生物素酶缺乏症[J].临床儿科杂志,2006,24(12):941-943. 被引量：19
  • 4许家喜.微波与有机化学反应的选择性[J].化学进展,2007,19(5):700-712. 被引量：46
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  • 9Yuan B F, Connor T R, Wang Y S. 6-Thioguanine and S(6)-Methyhhioguanine are Mutagenic in Human Cells [ J ]. ACS Chem Bio1,2010,5 ( 11 ) : 1021-1027.
  • 10Prokopcova H, Kappe C O. Palladium (O)-Catalyzed, Copper ( I )-Mediated Coupling of Boronic Acids with Cyclic Thioamides:Selective Carbon-Carbon Bond Formation for the Functionalization of Heterocycles [ J ]. J Org Chem, 2007, 72(12) :4440-4448.

引证文献3

化学研究与应用
2007年 第9期

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