肠缺血再灌注导致血浆降钙素基因相关肽水平增高

The elevation of plasma calcitonin gene related peptides caused by intestinal ischemia reperfusion in rats

经ＲＩＡ分析发现在大鼠肠缺血再灌注后血浆中降钙素基因相关肽（ＣＧＰＲ）较损伤前平均增加３．５倍，比假手术相应水平增加２．２倍，肺灌洗液中损伤组比假手术组又增加３９％。磷脂酶Ａ２阻断剂三氟拉嗪和环氧化酶抑制剂消炎痛预先腹腔治疗可增加ＣＧＲＰ在血浆中的浓度，而同时肺灌洗液中ＣＧＲＰ的含量减少，但体外局部用药二者可明显促进正常肺组织释放ＣＧＲＰ。结果表明，肠缺血／再灌注（Ｉ／Ｒ）诱导血浆中ＣＧＲＰ增加，磷脂酶Ａ２激活及其产物可能对肺和循环中ＣＧＲＰ的水平有明显的影响。

By radioimmunoassay, it was discovered that intestinal ischemia reperfusion caused a 3.5 fold increase of the CGRP in rat plasma, and a 2.2 fold elevation compared with sham group. In pulmonary lavage fluid, the level of CGRP was 39% heigher than that of sham. Intra peritoneal use of phospholipase A 2 or cyclooxgenase inhibitor (TRIF or INDO) caused an increase of CGRP in plasma but decrease in pulmonary lavage fluid. However, CGRP release from normal tissue was promoted by both above drugs in vitro experiment. The observations suggest that intestinal I/R injury may cause increase of plasma CGRP, PLA 2 activation and its metabolites release seem to have some influences on the plasma and pulmonary CGRP levels.