血清铁蛋白、同型半胱氨酸与急性脑梗死的关系

Correlation of Serum Ferritin and Homocysteine Levels in Patients with Acute Cerebral Infarction

目的探讨血清铁蛋白(SF)、同型半胱氨酸(Hcy)含量与急性脑梗死(CI)患者的关系。方法对60例急性脑梗死患者、50例健康对照者以放免法测定血清铁蛋白(SF),采用化学发光法检测血清同型半胱氨酸(Hcy),同时检测Hcy的代谢因子维生素B12(Vit.B12)、叶酸(Fa)含量。结果和健康对照组比较CI患者组血清SF、Hcy明显增高,P<0.01,Hcy的代谢因子叶酸和Vit.B12亦明显降低,P<0.01。结论血清铁蛋白、同型半胱氨酸与急性脑梗死密切相关,而同型半胱氨酸主要与叶酸和Vit.B12营养性缺乏有关,SF、Hcy、Vit.B12、Fa参与了CI的病理、生理过程。对急性脑梗死患者应注意监测Hcy并予相应治疗,以利于患者的康复。

Objective To study the correlation of serum ferritin （SF） and homocysteine （Hcy） in the aute cerebral infarction （CI） group. Methods 60 patients in acute CI group and 50 healthy control group were used radio-immunity determine ferritin and investigated by means of chemiluminescent immunoassay for homocysteine,folate and vitamin B12. Results The levels of serum ferritin and homocysteine in patients in acute CI group were dramatically higher than those in control group （P 〈0.01 ） . Folate and vitamin B12 was significantly decrease in patients in acute CI group than those in control group （P 〈0.01） . Conclusion Se- rum ferritin , homocysteine was correlation of acute cerebral infarction, and the homocysteine was correlation tropism deficiency of folate and vitamin B12. It was suggested that ferritin , homocysteine , folate and vitamin B12 could participate in the process of pathology and physiology in CI. Dynamic detection of serum ferritin , homocysteine ,folate and vitamin B12 and to give corresponding treat was helpful to recover for illness in CI.