幽门螺杆菌感染与缺铁性贫血临床研究

Clinical Study on Helicobacter Phyori Infection and Iron Deficiency Anemia

目的探讨幽门螺杆菌感染与缺铁性贫血的关系。方法选择伴慢性胃炎的IDA患者82例(观察组)和慢性胃炎无贫血患者60例(对照组)行快速尿素酶试验,内镜下组织病理检查;观察组中,Hp阳性患者70例随机分为A、B、C3组,A组(30例)给予硫酸亚铁和抗Hp治疗,B组(20例)给予硫酸亚铁和安慰剂治疗,C组(20例)给予抗Hp治疗;观察治疗前后患者的血红蛋白、红细胞计数、平均红细胞容积、网织红细胞、血清铁、血清铁蛋白等血液学指标的变化情况。结果观察组82例中70例Hp阳性,对照组60例中43例Hp阳性,两组间差异有显著性(P<0.01);观察组中A、C组与B组比较,治疗前后血液学指标改变及疗效差异有显著性(P<0.05)。结论Hp感染与IDA有一定相关性,抗Hp加铁剂是治疗Hp感染相关性缺铁性贫血的有效方法。

Objective To investigate the relationship between helicobacter pylori infection and iron deficiency anemia. Methods Rapid urcase test and gastroscopy were used to examine in 82 patients of IDA in association with chronic gastritis（study group）, 60 patients only with chronic gastritis（control group）. The study group was randomly divided into three groups（A,B,C）again. Group A（30 cases） was given ferrous sulfate and eradication ofH. pylori infection, group B（20 cases）was given ferrous sulfate and placebo, group C（20 cases）was given neradication ofH. pylori infection. Around the therapy, hemoglobin（Hb）, red blood cell, mean corpuscular volume, reticulocyte, serum iron and serum ferritin were measured on the patients of the study group. Results The cases with Hp positive were 70 in the study group and 43 in control group, the two groups had outstanding differences（P 〈 0.01）. The differences in change of hematologic al examinat ion and curative effect were obvious in patients of group A, C and of group B. Conclusion There is a certain correlation between H.pylori infection and IDA. It is effective for IDA in association with H.pylori infection to give ferrous sulfate and eradication of H.pylori infection.