摘要
目的探讨内分泌腺特异性血管内皮生长因子(EG-VEGF)在子宫内膜异位症(EM)的表达及其在EM发生发展中的作用。方法采用RT-PCR检测并比较VEGF mRNA和EG-VEGF mRNA在EM异位内膜和对照组正常内膜的表达及其相关性。结果①EM异位内膜的VEGF mRNA相对量(0.68±0.48)明显高于对照内膜(0.16±0.55)(P<0.05);但异位内膜的EG-VEGF mRNA相对量(0.05±0.56)与对照组内膜(0.025±0.25)相比,差异无显著性(P>0.05);②EM异位内膜的VEGF mRNA和EG-VEGF mRNA相对量相关性分析表明无相关性(P>0.05);与正常对照内膜的结果相同。结论EG-VEGF在EM有一定表达,但作用机制有待进一步研究。
Objective To study the expression of endocrine gland- derived vascular endothelial growth factor （EG - VEGF） in patients with endometriosis （EM）, and the role of EG - VEGF in pathogenesis of endometriosis. Methods Ectopic endometrium was collected from 30 patients with endometriosis, and normal endometrium was got from 16 control women. The expression of EG - VEGF mRNA and VEGF mRNA in the ectopic and normal endometrium were detected and compared by quantitative RT- PCR. Meantime, the association between them was investigated. Result （1） There was no significant difference in the expression level of EG - VEGF mRNA between the ectopic endometrium of endometriosis （0. 05 ± 0.56） and the normal endometrium of control group （0. 025 ± 0.25） （P〉0. 05）. But the expression level of VEGF mRNA in ectopic endometrium of endometriosis （0. 68±0. 48） was markedly higher than that in control group （0. 16±0.55） （P〈0. 05）. （2） A correlation was not found between VEGF mRNA expression and EG- VEGF mRNA expression in ectopic endometrium of endometriosis （P〉0.05）, and same as in the normal endometrium of control group. Conclusion Despite its expression in the endometriosis, the mechanism of EG - VEGF in the endometriosis remains to be further studied and confirmed.
出处
《中国妇产科临床杂志》
2007年第5期326-328,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
国家留学回国人员基金资助(2003年)
