氮杂环丙烷化合物在直链淀粉柱上的拆分

Separation of Aziridines Enantiomers on Amylase-tris(3,5-dimethylphenylcarbamate) Chiral Stationary Phase

在自制的直链淀粉-三(3,5-二甲基苯基氨基甲酸酯)(ADMPC)手性固定相上,对2种氮杂环丙烷对映体进行了手性拆分研究.系统选用了不同种类及不同含量的醇改性剂,详细考察了样品的保留时间和立体选择性.

Two enatiomers of aziridines have been chiral separated on amylase- tris （3, 5- dimethylphenylcarbamate） chiral stationary phase （CSP）, using hexane as the mobile phase with various alcohols as modifiers. The influence of the mobile phase composition on the enantioselectivity was discussed. The results showed that n-butanol was the best mobile phase modifier, and butanol-hexane （5. 0 ： 95.0, V/V） was the optimal mobile phase condition.