亚急性炎性脱髓鞘性多发神经根神经病的临床和病理

SSubacute inflammatory demyelinating polyradiculoneupathy: clinical and pathological studies

研究亚急性炎性脱髓鞘多发性神经根神经病的临床和病理特点。方法对６例亚急性炎性脱髓鞘多发性神经根神经病进行临床、腓肠神经活检光镜和电镜研究。结果患者的临床高峰在４～８周。临床表现主要为中等度瘫痪不伴呼吸衰竭，激素治疗有效。３例腓肠神经活检显示为脱髓鞘伴有单核细胞浸润。结论由于临床和病理结果与急性和慢性格林－巴利综合征不同，这些患者应考虑诊断亚急性炎性脱髓鞘多发性神经根神经病，以区别急性炎性脱髓鞘多发性神经根神经病和慢性炎性脱髓鞘多发性神经根神经病。

Objective To study the clinical and pathological characteristics of subacute inflammatory demyelinating polyradiculoneuropathy. Method Six patients with subacute inflammatory demyelinating polyradiculoneupathy were subjected to the clincal study, light and electron microscopic study of sural nerve. Results The patients had a progressive peak phase for 4 ～ 8 weeks. Clinical manifestations consisted basically of moderate paralysis without respiratory failure. They responded well to steroid therapy and recovered. Sural nerve biopsy performed in 3 of the patients showed demyelination associated with monocytic infiltration. Conclusion These dissimilar features acute or chronic cases of differentiated the 6 patients with subacute inflammatory demyelinating polyradiculoneuropathy from those with Guillain Barre syndrome in form of AIDP or CIDP.