微环境与树突状细胞的发育

Roles of the microenvironment on the development of dendritic cells

树突状细胞（DC）是专职的抗原递呈细胞（APC），体内的CD均来源于造血干细胞，在其分化成熟过程中各种微环境因素都起着不可忽视的作用。以往的研究曾报道过诸如TNF—α、GM—CSF、IL-4等细胞因子对（DC）生成的影响，最近又发现IL-10，IL-21和IL-15对DC的发育成熟也发挥巨大作用。除了细胞因子，胞间接触对DC的发育也有着深远的意义。探讨各种因素对DC的调控作用可以使我们更清楚的了解DC的发育过程并实现利用DC治疗各种自身免疫性疾病和肿瘤性疾病的目的。

Dendritic cells （DCS） possess specialized features as antigen-presenting cells. DC derives from hematopoitic stem cells and many factors play important roles on its development. Previous studies have documented the influences of cytokines such as TNF-α, GM-CSF, and IL-4. Current researches showed that cytokines like IL-10, IL-21, and IL-15 also impose immense influences on DCs development. Addition to cytokines, DC precursors developing in vivo receive signals from stromal cells and other cell types. Discussing the roles of factors in the environment will allow us understand the development of DCs and its roles in the therapies of tumorgenic and auto-immunity diseases.