苯接触的生物监测指标初步评估

THE PRELIMINARY VALUE OF THE MARKS OF THE BIOLOGICAL MONITORING IN WORKERS EXPOSED TO BENZENE

目的：探索可客观反映职业性苯危害的灵敏指标。方法：测定苯作业车间空气苯浓度和３３名苯作业工人及４名非苯作业工人志愿者苯接触后呼出苯浓度、血苯含量及尿酚排出量，并进行相关性分析。结果：空气苯浓度（４．５～３４８ｍｇ／ｍ３）与血苯含量呈明显正相关（Ｐ＜０．０５）；血苯含量与尿酚排出量呈非常显著正相关（Ｐ＜０．０１）。结论：在低浓度苯接触时，血苯是一个与毒性相关联的特异性敏感苯吸收指标；尿酚排出量可用作高浓度苯接触工人的生物监测指标。

Objective: To evaluate relationship between the benzene concentration in workplace and breath, the benzene content in blood and the phenol in urine in workers exposed to benzene. Results: There is a positive relationship between the benzene in work place and in blood in workers exposed to benzene (P<0.05); and a very significant positive relationship between the benzene in blood and the phenol in urine (P<0.01).Conclusion: The benzene in blood is a sensitive, specialand direct mark of absorption when a low level benzene exposure; the phenol in urine is a useful mark of the biological monitoring in workers exposed to benzene in high concentration.