湖北省首例人感染高致病性禽流感病例的流行病学调查

Epidemiological investigation of the first case infected with highly pathogenic human avian influenza in Hubei Province

目的通过对1例人感染高致病性禽流感病毒(H5N1)的调查分析,为科学防控提供依据。方法采用病例流行病学调查方法,调查病例发病经过、可能的感染来源、传播途径及暴露因素等,医学观察患者的密切接触者,同时对患者进行临床诊治、实验室检测。结果确诊1例人感染高致病性禽流感病毒(H5N1),经救治无效死亡。患者无明确病死禽接触史,有健康禽接触史。实验室检测鼻分泌物和下呼吸道灌洗物均分离出禽流感病毒H5N1,下呼吸道灌洗物禽流感病毒H5N1核酸阳性。患者的密切接触者中均未发现异常临床表现。结论存在感染来源不明的人禽流感病例,需加强不明原因肺炎监测和进一步研究人禽流感有关危险因素。

Objective To investigate and analyze the first case of highly pathogenic avian influenza virus infection （H5N1） and offer scientific basis for control of avian influenza infection in humans. Methods Epidemiological survey was carried out included the process of falling ill, possible infection source, transmission route and risk factors, eetc. Strict observation on those closely contacted with the patient was made. Meanwhile the patient treated pathologically examined. Results The patient was confirmed to be infected with highly pathogenic human avian influenza H5N1 virus as aseertained by expert group of Ministry of Health and died. The patient was no exposed to the dead or filed fowl, but to healthy fowl, The avian influenza virus H5N1 was detected from the samples of rhinal and trachea excrete. RNA testing of the trachea excrete sample was positive. No abnormal manifestations were observed among those closely contacted with the patient during strict medical observation. Conclusion The infection source of the patient was inexplicit, The surveillance of the avian influenza epidemic be sterengthened and the risk factors associated with avian influenza virus be surveyed in future.