垂体后叶素治疗肺结核咯血引起低钠血症52例临床分析

Clincal observation on the effect of hypophysin on 52 hyponatremia patients due to pulmonary tuberculosis hemoptysis

目的探讨垂体后叶素治疗肺结核咯血引起低钠血症的机制、临床特点及治疗。方法对2000年1月．2007年4月住院286例肺结核咯血患者静滴垂体后叶素治疗过程中引起低钠血症52例的临床资料进行回顾性分析。结果52例患者中，30例无临床症状，血清钠为（128±3）mmol／L，22例出现临床症状，血清为（116±8）mmol／L：恶心、呕吐12例，肌无力8例，肌痉挛7例，精神错乱6例，嗜睡6例，抽搐5例，昏迷误诊为结核性脑膜炎5例。结论肺结核咯血应用垂体后叶素治疗时，应动态监测血清钠浓度变化，注意低钠血症发生，以便及时纠正，防止严重并发症发生。

Objective To explore the mechanism, clinical characteristic and treatment of pulmonary tuberculosis hemoptysis patients with hypophysin leading to hyponatremia. Methods Retrospective analysis of the pulmonary tuberculosis hemoptysis patients with hypophysin leading to hyponatremia of 286 hospitalized eases during January 2000 - April 2007 was made. Results Of the 52 eases, 30 were without clinical symptom, the concentration of serum sodium was （128 ± 3）mmol/L, 22 had clinical symptom, the concentration of serum sodium was 116 ± 8）mmol/L; nausea and vomiting eeurred to 12 eases; myasthenia, myospasm, mental disorder, lethargy and muscular spasms occurred to 8,7,6,6 and 5 eases. Five were misdiagnosisd as eerbral tuberculosis, Conclusion When the hypophysin is used in treatment of pulmonary tuberculosis hemoptysis patients, the change of concentration of the serum sodium be monitored at any time and attention be paid to occurrence of hyponatremia and serious complications.