建立急性肺血栓栓塞症模型的初步研究

Preliminary study of establishment of acute pulmonary thromboembolism in dogs

目的:探讨急性肺血栓栓塞症(PTE)犬模型的建立及其相应的肺动脉压和病理变化。方法:将8只草犬随机分为空白组和模型组,分别给予假手术操作和静脉注入自体血栓。结果:模型组肺动脉压在建模后的4个时点均较基础水平显著升高。两组的肺组织病理形态有明显区别,模型组不仅有肺血管内血栓存在,炎症反应也较明显。结论:通过注入自体血栓可成功建立急性PTE犬模型,可为进一步研究PTE的发病机制及其干预治疗提供模型基础。

Objective To establish dog acute pulmonary thromboembolism（PTE） models and to evaluate the changes of pulmonary arterial pressure（PAP） and pathology of the models.Methods Eight dogs were randomly divided into a normal group in sham operation and a model group in injection of autologous blood clots.Results PAP of the model group was remarkably higher than that of the normal group at all 4 time points after model establishment.The difference showed statistical significance.The histopathologic and morphologic difference between the two groups was also significant.Not only could thrombosis in pulmonary vasculars be observed,but inflammatory reaction was observed also in the model group.Conclusions Acute PTE model in dogs successively established by means of injecting autologous blood clots provides a model basis for more studies of mechanism and therapies.