期刊文献+

慢性髓细胞性白血病患者移植前后Bcr-Abl融合基因检测和预处理的临床意义

下载PDF
导出
摘要 异基因造血干细胞移植是治疗慢性髓细胞性白血病(chronic myelogenous leukemia,CML)的重要手段之一。目前,移植治疗相关的并发症如移植物抗宿主病(graft versushost disease,GVHD)及感染等仍是移植失败的重要因素,但多数患者仍能获得治愈。本研究回顾分析我院近年CML慢性期患者异基因造血干细胞移植前预处理方案与移植后Bcr-Abl融合基因分子生物学检测的临床意义。
出处 《诊断学理论与实践》 2007年第4期374-375,共2页 Journal of Diagnostics Concepts & Practice
  • 相关文献

参考文献10

  • 1[1]Horowitz MM,Rowlings PA,PasswegJR.Allogeneic bone marrow transplantation for CML:a report from the International Bone Marrow Transplant Registry[J].Bone Marrow Transplant,1996,17(suppl 3):S5-S6.
  • 2[2]Sawyers CL.Chronic myeloid leukemia[J].N Engl J Med,1999,340(17):1330-1340.
  • 3[3]Hughes TP,Kaeda J,Branford S,et al.Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia[J].N Engl J Med,2003,349(15):1423-1432.
  • 4[4]Kantarjian H,Sawyers C,Hochhaus A,et al.Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia[J].N Engl J Med,2002,346(9):645-652.
  • 5[5]Cortes J,Talpaz M,O'Brien S,et al.Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate[J].Clin Cancer Res,2005,11 (9):3425 -3432.
  • 6[6]Davies SM,DeFor TE,McGlave PB,et al.Equivalent outcomes in patients with chronic myelogenous leukemia after early transplantation of phenotypically matched bone marrow from related or unrelated donors[J].Am J Med,2001,110(5):339-346.
  • 7[7]Crawley C,Szydlo R,Lalancette M,et al.Outcomes of reduced-intensity transplantation for chronic myeloid leukemia:an analysis of prognostic factors from the Chronic Leukemia Working Party of the EBMT[J].Blood,2005,106(9):2969-2976.
  • 8[8]Or R,Shapira MY,Resnick I.Nonmyeloablative allogeneic stem cell transplantation for the treatment of chronic myeloid leukemia in first chronic phase[J].Blood,2003,101(2):441-445.
  • 9[9]Radich JP,Gooley T,Bryant E,et al.The significance of bcr-abl molecular detection in chronic myeloid leukemia patients "late," 18 months or more after transplantation[J].Blood,2001,98(6):1701-1707.
  • 10[10]Press RD,Love Z,Tronnes AA,et al.Bcr-Abl mRNA levels at and after the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib mesylate-treated patients with CML[J].Blood,2006,107(11):4250-4256.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部