冰片抗炎镇痛作用的实验研究

Analgesic and Anti-inflammation Effect of Borneol

目的研究冰片的镇痛、抗炎作用。方法采用热板刺激、冰醋酸刺激小鼠扭体、冰醋酸致小鼠腹腔毛细血管通透性增加、角叉菜胶致大鼠足肿胀等方法研究冰片的镇痛及抗炎作用。结果冰片能明显抑制大鼠足跖肿胀度,其半数有效量(ED50)=0.3242g·kg-1;延长小鼠疼痛反应时间,ED50=0.3870g·kg-1;减少小鼠扭体次数,ED50=0.5813g·kg-1。同剂量条件下,冰片的镇痛效应比抗炎效应更为明显。结论冰片具有显著的镇痛、抗炎作用。

Objective To observe the analgesic action and anti - inflammation effect of borneol. Methods The analgesic action and anti - inflammation effect of borneol were observed by mouse hot - plate test, mouse acetic - acid - induced twisting test, mouse abdominal cavity capillary permeability increase test induced by acetic acid, and rat pedal swelling test induced by earrageenin. Results Borneol reduced the pedal swelling of rats, ED50 = 0. 3242 g · kg^-1, increased pain threshold in mice ED50 = 0. 3870 g · kg^-1, inhibited twisting response of mice obviously, ED50 = 0. 5813 g · kg^-1. In the same dose, the analgesic action of borneol was stronger than the anti - inflammatory effect. Conclusion Borneol has certain analgesic action and anti - inflammation effect.