环行电切术治疗重度宫颈上皮内瘤变和早期宫颈癌疗效观察

The research of LEEP for severe cervical intraepithelial neoplasia and early cervical carcinoma

目的:探讨环行电切术治疗重度CIN和早期子宫颈癌的有效性、可行性。方法:回顾性分析LEEP治疗61例重度CIN和15例早期子宫颈癌患者资料,观察LEEP手术时间、出血量、组织病理变化及术后随访结果,对其疗效进行分析。结果:LEEP手术平均时间约5.6min,术中出血量约9.4ml。术前术后病理相符71%(54/76),不符29%(22/76),其中17.1%(13/76)病理升级,11.9%(9/76)降级。切缘阴性率为93.4%(71/76),阳性率6.6%(5/76)。在9～27月随访期内,1例复发、2例残存CINI病灶,一次治愈率达96.1%。累计HPV转阴率达96.7%。LEEP的常见并发症有出血、感染。结论:LEEP治疗重度CIN和早期子宫颈癌是安全、有效的方法之一。

Objective： To investigate the efficacy and capability of LEEP to treat severe CIN and early cervical carcinoma. Methods： 61 severe GIN and 15 early cervical carcinoma patients were treated by LEEP, the operation time, hemorrhage, the change of histopathology and complications were analyzed retrospectively. Results： For the treatment of severe GIN and early cervical carcinoma with LEEP , the mean operation time was 5.6min, mean hemorrhage was 9. 4ml. After LEEP, 71% was consitent with pretreating histopathology, but 17. 1% was upgrade, and 11.9% was downgrade. The margin was negative in 93.4%. Followed up 9 ～ 27 month, 1 patient recurred with GIN Ⅰ, another 2 remained GIN I. The cure rate achieved up to 96. 1% and HPV elimination was 96.7%. The common complications of LEEP were hemorrhage and infection. Conclusion： The LEEP is a effective and safe way for the treatment of severe GIN and early cervical carcinoma.