骨桥蛋白、CD44v6在胰腺癌中的表达及其与临床病理特征的关系

Co-expression of OPN,CD44v6 in pancreatic cancer and the relationship between their expression and clinicopathological characteristics

目的:探讨骨桥蛋白(0PN)与CD44v6在人胰腺癌中的表达,并分析OPN、CD44v6与胰腺癌临床病理特性的关系。方法:应用免疫组织化学方法检测OPN、CD44v6在43例胰腺癌、34例癌旁组织中的表达。结果:43例胰腺癌标本中OPN、CD44v6阳性表达率分别为65.1%、62.7%,34例胰腺癌旁组织OPN、CD44v6阳性表达率均为20.6%;有淋巴结转移的胰腺癌组织中OPN、CD44v6表达阳性率分别为86.7%、80.0%,无淋巴结转移者为53.5%、53.6%,二者相比差异均有显著性(P<0.05);组织学分级为Ⅲ级的胰腺癌组织中CD44v6的表达率为85.7%,组织学分级为Ⅰ～Ⅱ级的胰腺癌组织中CD44v6的表达率为51.7%,二者相比差异有显著性(P<0.05);CD44v6与OPN的表达呈正相关,相关系数r为0.446(P<0.05)。结论:OPN、CD44v6在胰腺癌的浸润、转移中可能起重要作用,它们可作为胰腺癌浸润、转移及评估预后的指标。

Objective：To explore the expression of osteopontin（OPN）,CD44v6 in human pancreatic carcinomas and analyze the relationship between their expression and clinicopathologic features.Methods：The expression of OPN,CD44v6 was tested by immunohistochemistry in 43 cases of pancreatic carcinomas,34 cases of pancreatic paraneoplastic tissues.Results：In 43 cases of pancreatic carcinomas,the expression rates of OPN,CD44v6 were 65.1%,62.7% respectively;in 34 cases of pancreatic paraneoplastic tissues,the expression rates of OPN and CD44v6 were 20.6% both.OPN and CD44v6 expression was higher in carcinomas with lymph node metastases than that without metastases;CD44v6 expression was higher in carcinomas with histological gradeⅢ（P〈0.05）than that withⅠ～Ⅱgrade,and there were strong correlation between OPN and CD44v6（r=0.446）. Conclusion：The expressions of OPN and CD44v6 were higher in pancreatic carcinomas.They might play an important role in the progression of human pancreatic carcinomas and participat in the invasion and metastasis of pancreatic carcinomas.