缺血性脑血管病患者脑大动脉狭窄的分布及相关危险因素的研究

Distribution and analysis of related risky factor of intra and extra cranial arterial stricture in patients with ischemic cerebrovascular disease

目的:探讨缺血性脑血管病患者的脑大动脉血管狭窄情况及其与缺血性脑血管病危险因素的关系。方法:对347例缺血性脑血管病患者行数字减影血管造影(DSA)检查,按年龄分青中年组及老年组和按有无狭窄分为狭窄组和非狭窄组,对脑大动脉血管的狭窄率、狭窄程度、分布特点和危险因素进行统计分析。结果:缺血性脑血管病患者脑大动脉狭窄的发生率为152/347(43.8%),颅内动脉狭窄发生率80/152(52.6%),颅外动脉21/152(13.8%),颅内外血管狭窄并存51/152(33.6%),颅内外血管狭窄程度与年龄呈正相关(r_s=0.156,P<0.05),脑动脉狭窄组高血压、糖尿病、同型半胱氨酸、血总胆固醇、纤维蛋白原水平明显高于无动脉狭窄组(均P<0.05)。结论:缺血性脑血管病患者颅内动脉狭窄的发生率高于颅外。脑动脉狭窄的分布有年龄特征性。高血压、糖尿病、同型半胱氨酸、血总胆固醇、纤维蛋白原与脑动脉狭窄有关。

Objective：To explore the relationship between the circumstances of intra and extra cranial artery stenosis and the risk factors with ischemic cerebrovascular disease.Methods：347 patients were performed by using DSA,which were divided into young middle aged and old aged group by different age and the cerebrovascular stenosis（CVS）and non-stenosis（CVNS）group by with or without stenosis.Statistical analysis was used to evaluate the incidence,degree,distribution and risk factors of intra and extra cranial artery stenosis.Results：The prevalence of intra and extra cranial artery stenosis in ischemic cerebrovascular disease group is 152/ 347（43.8%）.The frequency of stenosis of intracranial artery was 80/152（52.6%）.The frequency of stenosis of extracranial artery was 21/152（13.8%）.The frequency of stenosis of intracranial and extracranial artery was 51/152（33.6%）.The degree of intra and extra cranial artery stenosis was positively correlated to the age（r_s=0.156,P〈0.05）.Hypertension（HBP）,diabetes（DB）,homocysteic （HCY）,total cholesterol（TC）,fibrin（FIB）,in CVS group were significantly higher than that in CVNS group（P〈0.05）.Conclusion： The incidence of stenosis of intracranial artery is higher than that of extracranial artery with cerebral artery stenosis of ischemic cerebrovascular disease.The distribution of cerebral artery stenosis correlated with age.The level of HBP,DB,HCY,TC and FIB was positively correlated to the rate of carotid artery stenosis.