单、双相抑郁症患者血清白介素-6水平的比较

A Contrast on Serum Interleukin-6 levels in Patients with Unipolar and Bipolar Depressive Disorders

【目的】研究单、双相抑郁症患者血清白介素-6(IL-6)水平,探讨其与单双相抑郁分型及抑郁严重程度的关系。【方法】研究对象被分为单相抑郁症组、双相抑郁症组和正常对照组,每组各30人。根据美国精神障碍诊断与统计手册第四版(DSM-Ⅳ)分别诊断单相和双相抑郁症,应用汉密尔顿抑郁量表17项版本(HAMD-17)筛选入组者并进行抑郁分级。用酶联免疫吸附技术(ELISA法)检测血清IL-6水平。【结果】双相抑郁症组血清IL-6水平较单相抑郁症组增高明显(P<0.01);血清IL-6水平与抑郁症组的严重程度有一定关系(P<0.05)。【结论】单、双相抑郁症之间血清IL-6水平有显著差异的,血清IL-6水平不同可能与抑郁症的亚型有关,与各型抑郁症的严重程度亦有关。

To investigate the levels of serum interleukin-6 in patients with unipolar and bipolar depressive disorders, and discuss whether it was associated with the types of unipolar and bipolar depressive disorders and severity of depression. [Methods] Objects were divided into three groups of unipolar depression, bipolar depression and control group. Thirty patients were enrolled in each group. The urtipolar and bipolar depressive disorders were diagnosed using Diagnostic and Statistical Manual of Mental Disorders-IV （DSM-IV）. Objects were screened and classified by Hamilton Depression Scale-17（HAMD-17）. The levels of serum IL-6 were detected by enzyme-linked immunosorbent assay （ELISA）. [Results]The levels of serum IL-6 in bipolar depression group were higher than those in unipolar depression group（ P〈0.01）. No significant difference was found between the levels of serum IL-6 and severity of unipolar and bipolar depression （ P 〈 0. 05）. [Conclusion]The levels of serum IL-6 are significant difference between unipolar and bipolar depression. The difference is possibly associated with the subtypes of depression and is not related to severity of depression.