不稳定型心绞痛患者血清同型半胱氨酸含量的变化

Changes of Serum Homocysteine in Patients with Unstable Angina Pectoris

【目的】探讨血清同型半胱氨酸含量(HCY)在不稳定型心绞痛(UAP)发展过程中的变化。【方法】65例患者分为3组:UAP组(n=23)、稳定型心绞痛(SAP)组(n=22)和对照组(n=20)。UAP组又分为有并发症组(n=17)和无并发症组(n=6)两个亚组。入院时取静脉血检查血糖、血脂(标准酶法)、血清HCY(色谱法)水平和肝、肾功能、C反应蛋白(CRP,化学发光法)等。UAP组48h后重复检测HCY、CRP。【结果】①UAP组CRP、HCY血清水平明显高于对照组(p<0.01);②SAP组CRP、HCY血清水平与对照组相比差异有显著性(P<0.05);③入院时,有并发症组血清HCY和CRP水平高于无并发症组(P<0.05);48h后,有并发症组的HCY、CRP血清水平较入院时高(P<0.05),而无并发症组较入院时差异无显著性(P>0.05)。【结论】48h前后血清HCY和CRP水平的变化,可能反映了疾病的活动程度和预后。

To assess the role of serum homocysteine in patients with unstable angina pectoris. [Methods]Sixty five patients were divided into 3 groups. Unstable angina pectoris（UAP, n = 23） ,Stable angina pectoris（SAP, n =22）and Control grouP（n=20）. UAP group were divided into 2 sub-groups： subgroup 1 comprised of 17 patients with a complicated in-hospital course, and subgroup 2 comprised of 6 patients with an uneventful course. In each patient, serum levels of homocysteine and C reaction protein（CRP） were measured at entry in UAP group, and measured 48 hours after admission, too. [Results]OThe mean serum HCY and CRP were higher in UAP group than in control group（ P〈0.01）. （2）There were significant differences in the serum HCY and CRP between the SAP and the control group（ P〈0.05）. The serum HCY and CRP in UAP subgroup 1 were higher than UAP subgroup 2（ P 〈0.05） . Furthermore, the serum HCY and CRP reexamined 48 hours after admission in UAP subgroup 1 were higher than those of UAP subgroup 2 on admission（ P 〈0.05）. KConclusion]The changes of serum HCY and CRP in 48 hours after admission are associated with a complicated hospital course.