丙戊酸钠与氟西丁联合治疗躯体形式障碍的疗效现察

Comparative Study of Sodium Valproate Accompanied with Fluoxetine Hydrochloride and Only Fluoxetine Hydrochloride in the Treatment of Somatoform Disorder

【目的】比较丙戊酸钠联用氟西丁与单用氟西丁治疗躯体形式障碍的临床疗效和安全性。【方法】将73例躯体形式障碍的患者,随机分为丙戊酸钠联用氟西丁组及氟西丁组,疗程4周,用汉密尔顿抑郁量表(HAMD)评定疗效,用副反应量表(TESS)评定不良反应。【结果】丙戊酸钠联用氟西丁组显效率67.6%,总有效率91.9%;氟西汀组显效率44.4%,总有效率75%,二组显效率比较,u=2.06,P<0.05,有显著差异,副反应无显著性差异。【结论】丙戊酸钠联用氟西汀治疗躯体形式障碍,疗效好于单用氟西丁治疗,而且安全。

To compare clinical effect and safety of sodium valproate accompanied with fluoxetine hydrochloride and only fluoxetine hydrochloride in the treatment of somatoform disorder. [Methods]Seventy-three patients were randomly divided into sodium vlaproate group and Fluoxetime hydrochloride group and were treated respectively for four weeks . The efficiency was assessed by Hamilton depression rating scale （HAMD） and the safety was assessed by treatment emergent symptom scale（TESS）. [Results]In the sodium valproate accompanied with fluoxetine hydrochloride group, the marked improvement rate was 67.6 %,and the total improvement rate was 91.9%. But in the only fluoxetine hydrochloride group, the marked improvement rate was 44.4 %,and the total improvement rate was 75%. There was significant difference in marked improvement rate（u=2.06, P 〈0.05） and there was no significant difference in adverse reactions in both groups. [Conclusion] Sodium valproate accompanied with Fluoxetine hydrochloride is safer and much more effective than Fluoxetine hydrochloride only in the treatment of somatoform disorder.