复杂冠状动脉病变患者血清低密度脂蛋白免疫复合物的变化及意义

Changes of serum low-density lipoprotein immune complexes in patients with complicated coronary lesion and their implication

目的:探讨低密度脂蛋白循环免疫复合物(LDL-IC)在复杂冠状动脉病变发生发展过程中的作用和临床意义。方法:采用酶联免疫吸附法(ELISA)测定139例冠心病组患者及111例正常对照组的血清LDL-IC浓度。根据冠状动脉造影结果将冠心病组分为多支病变组、双支病变组及单支病变组;弥漫性病变组及局限性病变组;重度狭窄组及轻度狭窄组进行比较。结果:①冠状动脉多支病变组患者LDL-IC水平显著高于双支病变组患者[(2.75±1.22)AUvs(2.35±0.83)AU,P<0.05]和单支病变组患者[(2.75±1.22)AUvs(1.82±0.50)AU,P<0.01]。②冠状动脉弥漫性病变组LDL-IC水平高于局限性病变组患者[(3.06±1.07)AUvs(1.72±0.32)AU,P<0.01]及正常对照组[(3.06±1.07)AUvs(1.55±0.71)AU,P<0.01]。③冠状动脉重度狭窄组LDL-IC水平高于轻度狭窄组患者[(2.88±1.10)AUvs(1.82±0.50)AU,P<0.01]及正常对照组[(2.88±1.10)AUvs(1.55±0.71)AU,P<0.01]。结论:LDL-IC与复杂冠状动脉病变的发生发展之间可能存在一定的相关性。

Objective：To study the significance of low- density lipoprotein immune complexes（ LDL-IC ） in the pathogenesis of complicated coronary lesion. Methods：Enzyme-linked immunosorbent assay （ELISA） was used to measure the serum LDL-IC in 139 patients with coronary heart disease and 111 normal controls. The patients were divided by coronary angiography into a multi-vessel diseased group, an ambi-vessel diseased group, mono-vessel diseased group; diffuse lesion group, a located lesion group, a serious stenoses group and a light stenoses group. Results： The LDL-IC level was significantly higher in the multi-vessel diseased group than in the ambi-vessel diseased grouo （ [ 2.75 ± 1.22 1 AU vs[ 2.35 ± 0.83 ] AU, P 〈 0.05 ） mono-vessel diseased group （ [ 2.75 ± 1.22 ] AU vs [ 1.82 ± 0.50 ] AU, P 〈 0.01 ）, in the diffuse lesion group than in located lesion group （ [ 3.06 ± 1.07 ] AU vs [ 1.72 ± 0.32]AU, P 〈0.01） and the control subjects （[3.06 ± 1.07] AU vs [ 1.55 ±0.71] AU, P 〈0.01）, and in the serious stenoses group than in the located lesion group （ [2.88 ± 1.10] AU vs [ 1.82 ±0.50] AU, P〈0.01） and than that in control subjects （[2.88±1. 10] AU vs [1.55 ±0.71] AU, P〈 0.01 ）. Conclusion ：LDL-IC might play some roles in the pathogenesis of complicated coronary lesion.