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SGK1的功能及在糖尿病肾病肾纤维化中的作用研究进展 被引量：1

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摘要 血清和糖皮质激素诱导的蛋白激酶1在糖尿病肾病肾小球硬化和肾间质纤维化的形成中起重要作用，本文就其发病机制和相关性作一综述。
作者 汪永辉（综述） 刘建国（审校） 王全胜（审校）
机构地区 武汉华中科技大学附属协和医院中西医结合科
出处 《国际泌尿系统杂志》 2007年第5期702-704,共3页 International Journal of Urology and Nephrology
基金 国家自然科学基金资助项目（30600810）
关键词 糖尿病肾病 纤维变性
分类号 R692.39 [医药卫生—泌尿科学]
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参考文献18

  • 1王全胜,张晓丽,王玉梅,张阿丽,邓安国,朱忠华,Florian Lang,冯玉锡.高糖通过血清和糖皮质激素诱导的蛋白激酶1通路促进人近端肾小管上皮细胞合成纤连蛋白[J].中华肾脏病杂志,2005,21(4):218-222. 被引量：10
  • 2王全胜,张晓丽,王玉梅,张阿丽,邓安国,朱忠华,冯玉锡.高糖通过血清和糖皮质激素诱导的蛋白激酶1通路促进人系膜细胞合成纤连蛋白[J].中华医学杂志,2005,85(23):1591-1595. 被引量：8
  • 3Webster MK, Goya L. Characterization of sgk, a Novel Member of the Serine/Threonine Protein Kinase Gene Family Which Is Transcriptionally Induced by Glucocorticoids and Serum. Molecular And Cellular Biology, 1993,13:2031 - 2040.
  • 4Sei-yu Chen, Aditi Bhargava. Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci, 1999, 96 (5) :2514-2519.
  • 5Kobayashi T, Cohen P. Activation of serum - and glucocorticoid - regulated protein kinase by agonists that activate phosphatidylinositide 3 - kinase is mediated by 3 - phosphoinositide - dependent protein kinase - 1 ( PDK1 ) and PDK2. Biochem J, 1999 ; 339 ( Pt 2 ) : 319-328.
  • 6McCormick JA, Bhalla V, et al. SGK1 : a rapid aldosterone - induced regulator of renal sodium reabsorption. Physiology (Bethesda). 2005 ,20 : 134 - 139,
  • 7Vallon V, Lang F. New insights into the rote of serum - and glucocorticoid - inducible kinase SGK1 in the regulation of renal function and blood pressure. Curr Opin Nephrol Hypertens,2005,14 ( 1 ) :59-66
  • 8David Pearce, Thomas R, Kleyman, et al. Salt, sodium channels, and SGK1. J Clin Invest,2007,117:592-595.
  • 9Rauh R, Dinudom A, Stimulation of the epithelial sodium channel (enac) by the serum - and glucocorticoid - inducible kinase (sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition, pflugers Arch, 2006, 452 (3) : 290 - 299.
  • 10Friedrich B, Feng Y. The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na + channel alpha, beta, gamma - ENaC. pflugers Arch ,2003,445 ( 6 ) :693 - 696.

二级参考文献14

  • 1张晓丽,王全胜,王玉梅,朱忠华,邓安国,冯玉锡.高糖对人肾小管上皮细胞和系膜细胞表达血清和糖皮质激素诱导蛋白激酶1的影响[J].中华肾脏病杂志,2004,20(5):330-333. 被引量：9
  • 2王全胜,张晓丽,王玉梅,邓安国,朱忠华,冯玉锡.血清和糖皮质激素诱导的蛋白激酶在糖尿病肾病小鼠中的表达及意义[J].中华肾脏病杂志,2004,20(6):442-445. 被引量：16
  • 3Lang F,Klingel K,Wagner CA,et al. Deranged transcriptional regulation of cell volume sensitive kinase hSGK in diabetic nephropathy. Proc Natl Acad Sci USA, 2000,94: 8157-8162.
  • 4Kobayashi T, Cohen P. Activation of serum-and glucocorticoidregulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositidedependent protein kinase-1 (PDK1) and PDK2. Biochem J,1999,39: 319-328.
  • 5Ziyadeh FN. Significance of tubulointerstitial changes in diabetic renal disease. Kidney Int, 1995,54 Suppl: S10-S13.
  • 6Kikkawa R, Koya D, Haneda M. Progression of diabetic nephropathy. Am J Kidney Dis, 2003,41(3 Suppl 1): S19-S21.
  • 7Park J, Leong ML,Buse P,et al. Serum and glucocorticoidinducible kinase (SGK) is a target of the P1 3-kinasestimulated signaling pathway. EMBO J, 1999,18:3024-3033.
  • 8Kumar JM, Brooks DP, Olson BA, et al. SGK, a putative serine/threonine kinase, is differentially expressed in the kidney of diabetic mice and humans. J Am Soc Nephrol,1999,10: 2488-2494.
  • 9Setiawan I, Henke G, Feng Y, et al. Stimulation of xenopusoocyte Na+, K+ ATPase by the serum and glucocorticoiddependent kinase sgk1.Eur J Physiol, 2002, 444:426-431.
  • 10Wang J, Barbry P, Maiyar AC, et al. SGK regulates insulin and mineralocorticoid regulation of epithelial sodium transport.Am J Physiol Renal Physiol, 2001,280: F303-F313.

共引文献14

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二级引证文献6

国际泌尿系统杂志
2007年 第5期

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