广西85例肝癌患者庚型肝炎病毒感染的血清学研究

A serological study on hepatitis G virus(HGV)infection in patients with hepat ocellular carcinoma.

对肝癌高发区的85例肝癌患者血清采用套式PCR(nested -PCR)方法检测庚型肝炎病毒核糖核酸(HGV -RNA) ,并用相同方法检测了HCV -RNA;HBV -DNA则采用单次PCR检测,阴性者再用套式PCR证实。结果提示:85例肝癌患者中,11例患者可检出HGVRNA,占总受检例数的12.9 %;而HCV -RNA,HBV -DNA阳性者分别为15例及68例,占17.6 %和80%。初步证明广西部分肝癌病人血清中存在HGV感染,作者认为:HBV仍是广西肝癌的主要的感染因素,其次是HCV感染。但庚型肝炎病毒感染对肝癌的作用机理尚待进一步研究。

In order to study a new hepatitis virus(HGV) infection and its role in patients with hepatocellular carcinoma in GuangXi which is a hepatocellular carcinoma endemic area.HGV-RNA,HCV-RNA,HBV-DNA in the sera of 85 patients with hepatocellular carcinoma from that area were detected using nested-PCR methods(HBV-DNA was firstly detected by single-PCR then the negative were confirmed by nested-PCR).The results showed that 11 out of 85 patients(12.9%)were seropositive for HGV-RNA,and the seropositive rate for HCV-RNA,HBV-DNA were 17.6%(15/85)and 80%(68/85) respectively among these patients.The preliminary conclusions are as follows:There are HGV infection in sera of some patients with hepatocellular carcinoma.Of the factors in hepatocellular carcinoma occurrence,HBV infection still plays a major role,and HCV is less important in the development of HCC compared with HBV.The role mechanism of HGV infection in hepatocellular carcinoma await further study.