摘要
目的:探讨防风、刺蒺藜单用及二药合用的抗Ⅰ型变态反应作用。方法:采用小鼠同种PCA反应模型、大鼠颅骨骨膜肥大细胞脱颗粒模型及Schu lz-Dale反应模型进行观察。结果:防风、刺蒺藜、防刺合煎剂均可明显抑制小鼠同种PCA,大鼠颅骨骨膜肥大细胞脱颗粒及Schu lz-Dale反应。结论:防风、刺蔟藜、防刺合煎剂均有抗Ⅰ型变态反应作用,防风与刺蔟藜合用的效应较单用为相加。
AIM : To study the effects of Radix Saposhnikoviae (RL) and Feutus Trbuli (FI) used singly and eombinedly on antagonizing type Ⅰ allergy, such as passive cutaneous anaphylaxis (PCA) , released model from mast cell granules, Schulz-Dale respond. METHODS: Mouse and rat models mainly induced by IgE were used in experiments. RESULTS: RL and FI used singly and combinedly could significantly inhibit PCA of same species of mice, the degranulation of mast cells of skull in rats and Schulz-Dale response. CONCLUSION: Both RL and FI respectively have antagonistic effect on type Ⅰ allergy and RL in combination with FI will possess more satisaetory effect
出处
《中成药》
CAS
CSCD
北大核心
2007年第9期1269-1271,共3页
Chinese Traditional Patent Medicine
关键词
防风
刺蒺藜
抗Ⅰ型变态反应
Radix Saposhnikoviae
Feutus Trbuli
antagonizing type, Ⅰ allergy