防风与刺蒺藜抗Ⅰ型变态反应的实验研究

Experimental study of Radix Saposhnikoviae and Feutus Trbuli on antagonizing type Ⅰ allergy

目的:探讨防风、刺蒺藜单用及二药合用的抗Ⅰ型变态反应作用。方法:采用小鼠同种PCA反应模型、大鼠颅骨骨膜肥大细胞脱颗粒模型及Schu lz-Dale反应模型进行观察。结果:防风、刺蒺藜、防刺合煎剂均可明显抑制小鼠同种PCA,大鼠颅骨骨膜肥大细胞脱颗粒及Schu lz-Dale反应。结论:防风、刺蔟藜、防刺合煎剂均有抗Ⅰ型变态反应作用,防风与刺蔟藜合用的效应较单用为相加。

AIM ： To study the effects of Radix Saposhnikoviae （RL） and Feutus Trbuli （FI） used singly and eombinedly on antagonizing type Ⅰ allergy, such as passive cutaneous anaphylaxis （PCA） , released model from mast cell granules, Schulz-Dale respond. METHODS： Mouse and rat models mainly induced by IgE were used in experiments. RESULTS： RL and FI used singly and combinedly could significantly inhibit PCA of same species of mice, the degranulation of mast cells of skull in rats and Schulz-Dale response. CONCLUSION： Both RL and FI respectively have antagonistic effect on type Ⅰ allergy and RL in combination with FI will possess more satisaetory effect