雅叫哈顿散药效学研究I

Pharmacodynamics of Yajiao Hadun San Ⅰ

目的:研究雅叫哈顿散(蔓荆茎叶,藤苦参,小百部,羊耳菊根,苦冬瓜,箭根薯)的药理作用。方法:采用干酵母致热法、扭体反应法、足跖肿胀及耳肿胀法和碳粒廓清等方法,观察药物在解热镇痛、抗炎及对免疫功能的影响等方面的药理作用。结果:雅叫哈顿散可抑制由干酵母所致的大鼠体温升高;减少腹腔注射醋酸后小鼠扭体反应出现的次数;抑制蛋清所致的小鼠足跖肿胀和巴豆油所致的小鼠耳肿胀;提高小鼠对胶体炭粒的清除速度。结论:雅叫哈顿散具有解热镇痛、抗炎和提高小鼠单核巨噬细胞吞噬功能的作用。

AIM： To study the pharmacodynamics of Yajiao Hadun San（ Vitex trifolia; streptocaulon griffibhii; Asparagus pseudofilicinus; Inula cappa; Benincasa hispida; Tacca esquirolli ）. METHODS ： The pyrexia model rat induced with active yeast, the mice＇s auricular swelling test caused by croton oil; the mice＇s toe swelling test caused by albumen; the mice＇s twisting body test caused by the irritation of acetic acid and the mice＇s carbon clearance test were used to determine antipyretic, analgesic, anti-inflammation effect and immunity function of Yajiao Hadun San. RESULTS： Yajiao Hadun San could reduce the anus temperature of the pyrexia model rat, inhibit the mice＇s toe and auricular swelling, reduce the times of twisting body sharply and also increase the rate of eliminating colloid carbon in mice. CONCLUSION： Yajiao Hadun San has certain antipyretic, anti-inflammation, analgesic effect and enhance the phagocytosis of mono-karyon macrophage in mice.