慢性淋巴细胞白血病DNA甲基化谱的研究进展
摘要
各种类型肿瘤具有特征性的DNA甲基化模式。本文就慢性淋巴细胞白血病（CLL）DNA甲基化谱、DNA甲基化在CLL发病机制、预后评估中的作用等方面作一综述，阐明CLL与基因DNA甲基化的关系。
出处
《国际输血及血液学杂志》
CAS
2007年第5期421-424,共4页
International Journal of Blood Transfusion and Hematology
基金
江苏省医学领军人才资助
江苏省自然科学基金项目（BK2007249）
江苏省社会发展基金项目（BS2007075）
参考文献19
-
1Esteller M, Corn PG, Baylin SB, et al. A gene hypermethylation profile of human cancer. Cancer Res,2001,61(8) :3225-3229.
-
2Chim C, Fung T, Wong K,et al. Methylation of INK4 and CIP/KIP families of cyclin-dependent kinase inhibitor(CKl) in Chronic Lymphocytic Leukemia (CLL) in Chinese. J Clin Pathol, 2006,24.[Epub ahead of print]
-
3Tsirigotis P, Pappa V, Labropoulos S, et al. Mutational and methylation analysis of the cyclin-dependent kinase 4 inhibitor (p16INK4A) gene in chronic lymphocytic leukemia. Eur J Haematol, 2006,76(3) :230-236.
-
4Valganon M, Giraldo P, Agirre X, et al. p53 Aberrations do not predict individual response to fludarabine in patients with B cell chronic lymphocytic leukaemia in advanced stages Rai Ⅲ/Ⅳ. Br J Haematol, 2005,129( 1 ) : 53-59.
-
5Venkatachalam S, Shi YP, Jones SN,et al. Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J, 1998, 17 (16): 4657-4667.
-
6Corcoran M, Parker A, Orchard J, et al. ZAP-70 methylation status is associated with ZAP-70 expression status in chronic lymphocytic leukemia. Haematologica, 2005,90(8):1078-1088.
-
7Mertens D, Wolf S, Schroeter P, et al. Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B-cell chronic lymphocytic leukemia. Blood,2002,99(11):4116-4121.
-
8Hammarsund M, Corcoran MM, Wilson W, et al. Characterization of a novel B-CLL candidate gene-DLEU7-1ocated in the 13q14 tumor suppressor locus . FEBS Lett,2004 ,556(1- 3):75-80.
-
9Gong XQ, Li L. Dermo-1, a multifunetional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation. J Biol Chem, 2002, 277(14):12310-12317.
-
10Maestro R, Dei Tos AP, Harnamori Y,et al. Twist is a potential oncogene that inhibits apoptosis. Genes Dev , 1999,13(17) : 2207- 2217.
-
1薄陆敏,李兆申,高军.胰腺癌DNA甲基化谱研究进展[J].胰腺病学,2007,7(5):348-350.
-
2张晓兵,刘泽军.胃癌DNA甲基化谱研究进展[J].世界华人消化杂志,2002,10(12):1454-1457. 被引量：4
-
3刘洋,胡越,凌志强.肿瘤抑制基因DNA甲基化与宫颈癌研究进展[J].国际妇产科学杂志,2010,37(5):322-324. 被引量：6
-
4张品伟,李志刚,吴敏媛.DNA甲基化在白血病中临床研究进展[J].临床和实验医学杂志,2006,5(12):2028-2029.
-
5唐勇,胡钧培.慢性髓系性白血病DNA甲基化及与临床相关性研究进展[J].中国实验血液学杂志,2008,16(6):1482-1486. 被引量：1
-
6五且昆.吐尔逊,陈艳,李惠武.nm23-H1基因CpG岛甲基化与食管癌的关系[J].地方病通报,2009,24(2):72-74. 被引量：1
-
7董倩倩,刘晓峰,李文波,尚瑞莲,孙自勤,魏志.胃癌组织中micro RNA-375基因DNA甲基化及临床意义[J].中国现代医学杂志,2013,23(26):30-33. 被引量：2
-
8方建晨,苏祖兰.淋巴瘤的表观遗传学及其临床意义[J].国际肿瘤学杂志,2006,33(1):64-67.
-
9房静远,萧树东,东舜时,施尧,江绍基,周筱梅,钱莲芳.人胃癌总基因DNA与c-myc、c-Ha-ras基因甲基化的改变[J].肿瘤,1996,16(2):92-94. 被引量：1
-
10彭涛,李曙光.DNA甲基化与胃癌关系的研究进展[J].山东医药,2015,55(1):101-103. 被引量：5
