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猪囊尾蚴dUTPase的同源建模及分析 被引量：6

Homologous modeling and analysis of Cysticercus cellulosae dUTPase
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摘要 通过SWISS-MODEL服务器对猪囊尾蚴dUTPase(Cysticercus cellulosae dUTPase,CY dUT-Pase)进行同源建模,用SPDBV和DSViewer对模型进行修饰,模型经WHATIF服务器进行质量评估。对已知dUTPase的晶体结构分析后,推测CY dUTPase属于同源三聚体,通过SymmDock服务器进行CYdUTPase三聚物的分子对接,并与人dUTPase 3D结构叠合。结果表明,建立的CYdUTPase 3D模型是成功的,具有良好的真实性,CYdUTPase三级结构的预测为此酶的结构功能研究和新型抗囊虫药物的开发奠定了基础。 The 3D protein structure model of Cysticercus cellulosae dUTPase（CY dUTPase） was generated by the SWISS-MODEL. The model was refined by SPDBV and DSViewer, and analyzed by the WHAT IF program. The presumed CY dUTPase belonged to homotrimer which was generated by Symm- Dock and superposition with 3D structure of human dUTPase. In conclusion, model of CY dUTPase was made successfully,which provided the material foundation for a novel drug against C. cellulosae.
作者 刘振勇 才学鹏
机构地区 中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室甘肃省动物寄生虫病重点实验室
出处 《中国兽医科学》 CAS CSCD 北大核心 2007年第9期742-745,共4页 Chinese Veterinary Science
基金 国家高技术研究发展计划(863)项目(2006AA10A207)
关键词 DUTPASE 同源建模 模型分析 dUTPase homologous modeling analysis of the model
分类号 S852.734 [农业科学—基础兽医学]
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参考文献11

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共引文献2

同被引文献19

  • 1张守发,鞠玉琳,李学一,吴相律.不同抗原在兔豆状囊尾蚴病血清学诊断中的研究[J].延边农学院学报,1994,16(2):98-102. 被引量：16
  • 2周永学,杜爱芳,张雪娟,吴文育.我国兔豆状囊尾蚴病的研究进展[J].中国养兔,2006(1):25-28. 被引量：26
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引证文献6

二级引证文献16

中国兽医科学
2007年 第9期

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