摘要
目的:针对严重不良反应问题,探讨中药注射剂的发展道路应该如何走。方法:参考有关文献并结合实际加以分析概括,提出科学的数量分析方法、生物检定统计法及黄金区域方法。结果和结论:用数量分析方法使中药注射剂的研究纳入科学的轨道;用生物检定统计法来鉴定目前难以掌握理化性质的药物的效价、有效率及毒副作用;用黄金区域方法改善使用中药注射剂剂量不准的问题。上述3方法综合应用可取得一定成效。
OBJECTIVE: To discuss the future of Traditional Chinese medicine injection in view of the serious adverse drug reactions (ADR) induced by the traditional Chinese medicine injections (TCMI). METHODS: The future of TCMI was analyzed based on pertinent literature and the reality. And scientiflc-quantltative analytical method, bioassay-statistical method and golden area distinction were put forward. RESULTS & CONCLUSION: The traditional Chinese medicine for injection can be led to a scientific track by using quantity analytical method; for those drugs with unclear physico-chemical properties, whose potency, effective power, toxic and adverse reactions can be identified by using bioassay-statistlcal method; and the inaccuracy in dosage of TCMI can be improved through golden area distinction. Satisfactory outcome can be achieved if the above 3 methods were applied concomitantly.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第27期2081-2083,共3页
China Pharmacy
关键词
数量分析
生物检定统计法
黄金区域
Scientific-quantitative analytical
Bioassay-statistical method
Golden area distinction