酚磺乙胺预防窒息新生儿颅内出血的随机对照试验

Randomized and Controlled Study on the Preventive Effects of Ethamsylate on Intracranial Hemorrhage in Newborn Infants with Asphyxia

为了探讨酚磺乙胺对窒息新生儿颅内出血(ICH)的预防效果,将145例窒息新生儿随机分为两组。甲组(73例)接受一般综合疗法,乙组(72例)除一般疗法相同外,同时给予酚磺乙胺治疗。结果显示:(1)乙组患儿ICH发生率和病死率均低于甲组(0.333:0.572;0.153:0.315,P值分别为:P<0.01,P<0.05);(2)早期用药效果优于晚期用药者(X^2=4.42,P<0.05);(3)对早产儿、足月儿及过期产儿的预防效果,无明显统计学差异(X^2≥1.207,P>0.05)。结果提示酚磺乙胺对窒息新生儿ICH的预防能起重要作用。

To investigate the preventive effects of ethamsylate on intracranial hemorrhage (ICH) newborn infants with asphyxia, 145 newborn infants with asphyxia were divided into 2 groups. The group A (73 cases) received ordinary treatment and the group B was given the ordinary treatment plus ethamsylate. Our results showed that 1) the ICH incidence and mortality of infants in group B were lower than those in Group A (0.333 ?0.5; 0.153 : 0.315, P<0.01;P<0.05); better effects were achieved if the treatment was started early (X2= 1.207; P<0.05). No statistically significant difference was found in the preventive effects among premature, full-term and post-term infants. Our results suggest that the ethamsylate may play an important role in the prevention in ICH in asphyxiated newborn infants.