癌变机制理论研究中的几点思考

Several Philosophical Thoughts on the Study of Tumorigenic Mechanism Theory

恶性肿瘤的形成是一个多步骤过程，涉及到多个癌基因的活化及抗癌基因功能的丧失。以往对肿瘤发生机制的研究多集中于这些复杂的遗传学改变所致的肿瘤细胞增殖失控。然而维持组织内环境的稳定不但依赖于细胞生长速度，而且与细胞凋亡有关。本文从细胞及分子水平叙述了癌变机制理论研究的进展并从哲学角度加以分析，以期为探讨真正的癌变机制，为进一步从分子水平上诊断和治疗肿瘤提供理论指导。

Tumor progression is generally regarded as a mutistep process that involving the activation of oncogenes and inactivation of antioncogenes.Until recently,most of the studies on the pathogenesis of cancer have focused on the regulation of cell proliferation.As matter of fact,in multicellular organisms,homeostasis is maintained through a balance between cell proliferation and cell death(apoptosis).The progress of tumorigenic mechanism theory has simply introduced and analyzed in philosophical aspect in this paper for finding the actual tumorigenic mechanism and providing the theoretical guide in the diagnosing and treating of tumor from molecular level.