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去纤酶对高血脂兔血小板功能、纤溶系统、血液流变学的影响 被引量：2

The effects of defibrase on platelet function, fibrinolytic activity and theology in rabbits on high cholesterol diet
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摘要 观察了食饵性高血脂对新西兰兔血小板功能、纤溶系统和血液流变学的影响以及去纤酶的调节作用。结果发现,高血脂能引起兔的血小板数增加,粘附力增强,血液粘滞性增加,红细胞流动变慢,呈现高凝和低纤溶状态,且主动脉形成明显粥样斑块。去纤酶在降低血脂的同时,可明显降低血小板的粘附力,降低血液粘滞性,呈现低凝和高纤溶状态,其主动脉粥样斑块亦明显减轻和缩小。 Defibrase purified from the venom of agkistrodon acutus is being widely used in the treatment of vascular thrombotic diseases, but there has been no report of using defibrase for the prevention of atherosclerosis. The present study is to investigate the effect of defibrase for the prevention of atherosclerosis in rabbits. In conclusion, intravenous injection of defibrase can reduce TC, inhibite platelet function, increase plasma fibrinotytic activity and reduce blood viscosity. Through these changes, atherosclerosis can be prevented to some extent by using defibrase.
作者 唐亚辉 李次芬
机构地区 海军总医院血液实验室
出处 《中国病理生理杂志》 CAS CSCD 北大核心 1997年第2期137-140,共4页 Chinese Journal of Pathophysiology
关键词 血脂过多 血小板 纤维蛋白溶酶 血液流变学 Hyperlipidemia · Blood plateletso Fibrinolysin · Rheology
分类号 R589.202 [医药卫生—内分泌]
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参考文献2

  • 1李次芬，中华血液学杂志，1990年，11卷，9期，461页
  • 2宋敏，中华心血管病杂志，1988年，1期，45页

同被引文献18

  • 1郭淑英.抗栓酶-3号治疗糖尿病并发症及其对血浆6-keto-PGF1,TXB2,FN和血脂的影响[J].中国医科大学学报,1991,20:68-70.
  • 2[1]Afek A, George J, Gilburd B, et al. Immunization of low-density lipoprotein receptor deficient (LDLRD) mice with heat shock protein 65 (HSP-65)promotes early atherosclerosis [J ]. J Autoimmun,2000,14(2): 115-121.
  • 3[2]Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s[J]. Nature, 1993, 326 (6423) :801-806.
  • 4[3]Krishnaswamy G, Kelley J, Yerra L,et al. Human endothelium as a source of multifunctional cytokines:molecular regulation and possible role in human disease[J]. J Interferon Cytokine Res, 1999,19 ( 1 ) : 91 -104.
  • 5[4]Steiner S,Gatlin CL, Lennon JJ ,et al. Cholesterol biosynthesis regulation and protein changes in rat liver following treatment with fluvastatin [J ]. Toxicol Lett,2001,120(5) :369-377.
  • 6[6]Soeki T, Tamura Y, Shinohara H, et al. Plasma concentrations of fibrinolytic factors in the subacute phase of myocardial infarction predict recurrent myocardial infarction or sudden cardiac death[J]. Int J Cardiol, 2002,85(3) :277-283.
  • 7[7]Maresca G,Di Blasio A, Marchioli R,et al. Measuring plasma fibrinogen to predict stroke and myocardial infarction an update[J]. Arterioscler Thromb Vasc Biol,1999,19(12):1 368-1 377.
  • 8[8]de Maat MP, Bladbjerg EM, Drivsholm T. Inflammation, thrombosis and atherosclerosis: results of the Glostrup study[J]. J Thromb Haemost, 2003,1 (5):950-957.
  • 9[9]Oubina MP,De LH,Vazquez PS,et al. Valsartan improves fibrinolytic balance ir atherosclerotic rabbits [J].J Hypertens,2002,20(2): 303- 310.
  • 10[10]Wiesbauer F, Kaun C, Zorn G, et al. HMG CoA reductase inhibitors affect the fibrinolytic system of human vascular cells in vitro: a comparative study using different statins[J]. Br J Pharmacol, 2002, 135 (1):284-292.

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中国病理生理杂志
1997年 第2期

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