摘要
为了解急性髓细胞白血病(AML)H-ras基因点突变的情况,应用聚合酶链反应和限制性酶切图谱分析技术,对55例初诊AML患者进行了检测,发现16例(29.1%)存在H-ras基因点突变,此突变与AML的发生及某些临床指标有一定关系。H-ras基因突变可望成为AML诊断分型、指导治疗及判断预后的一项有价值的指标。
To inquire into the situation of H ras gene point mutation in acute myeloid leukemia(AML),55 cases of AML were detected.The result showed that 16 cases(29.1%) contained H ras gene point mutation,and the mutation had certain correlation with leukemogenesis and some clinical parameters of AML.H ras gene mutation may probably be used as valuable predictor in typing diagnosis,directing treatment and determing outcome of AML.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
1997年第2期82-84,共3页
Chinese Journal of Medical Genetics