食管癌三维适形放射治疗疗效的Meta分析

Meta-analysis of Three Dimensional Conformal Radiotherapy for Esophageal Cancer

目的分析三维适形放射治疗技术(3-DCRT)治疗食管癌的疗效和放射毒性反应。方法检索国内有关数据库查找符合条件的临床随机对照试验,采用Meta分析方法,对国内公开发表的有关3-DCRT治疗食管癌的临床随机对照试验研究文献进行综合分析,在RevMan4.2.7软件中统计分析相应的研究指标。结果有8项独立的临床随机对照试验研究进入了本次meta分析。3-DCRT组的近期疗效,1、2、3年局控率及1、2、3年生存率均优于对照组(p<0.01)。两组毒副反应的差异无统计学显著性意义。结论3-DCRT治疗食管癌的近期疗效优于常规放射治疗方法,远期疗效和毒副反应有待进一步观察随访和研究。

Objective To evaluate the clinical results and radiation toxicities of three dimensional conformal radiotherapy （3-DCRT） for esophageal cancer. Methods We searched all data by computer in CBM, CNKI and VIP full text database and filtrated out eligible experiments after referring to theirs abstracts and full texts. Then systematic and synthetical analysis of the studies was conducted in meta-analysis software RevMan 4.2.7. Results Eight experiments accorded with the criterion of the study were analyzed, The 1-, 2- and 3-year local control rates, 1-, 2- and 3-year survival rates of 3-DCRT group were superior to CF group（p〈0.01）. 1 and 2 Grade response rate of 3-DCRT group was higher than CF group （p〈0.01）. Between the two groups, there was no significant difference in radiation toxicities. Conclusions The short-term local control rate and survival rate of patients with esophageal cancer treated by 3-DCRT is superior to conventional radiotherapy. However, long-term results need further study which involves prolonged follow-up.