天津地区戊型肝炎血清学及临床特征探讨

serological and Clinical Characteristics of Hepatitis E in Tianjin Area

对192例戊型肝炎(HE)住院患者血清学、临床特征进行分析,探讨天津地区HE流行、发病特点。1.HE占病毒性肝炎20％,中年男性居多。2.肠道内感染占78.6％;5例有近期输血史(2.6％)。提出HE存在血源传播的可能。3。临床表现类似甲型肝炎(HA),但不少方面有别于HA:HE只表现转氨酶(ALT)及胆红素(Bil)升高,未发现有慢性过程;重叠感染ALT及Bil均低于单纯HE(P<0.01),提出HEV与其它病毒间存在相互抑制作用。并提出对献血员做HEV筛选十分必要。

By analysing 192 patients with hepatitis E (HE) and their clinical characteristics, the investigation was made to apprroach the transmission of HE in Tianjin area. The results showed that:1. 20 percent of total viral hepatitis diseases are HE. The majority of HE patients was middle-aged male. 2.78.6 Percent of HE patients were infected through intestines. Five of them had blood transfusion recently(2. 6%). The data showed that HE virus might be transmitted by blood transfusion. 3. Clinical characteristics of HE was similar to HA, it showed only the departure of ALT and BIL,there was no chronic process. The levels of ALT and BIL in co-infection were lower than those in simple HE,which meant HEV and other virus might restrain each other. The importance of testing the donors' blood for HE virus was discussed-