摘要
冠心病心衰患者15例,每天服用地高辛0.125mg或0.25mg,当血清地高辛浓度(SDC)达稳态后,加服卡托普利8天。结果表明:卡托普利可增加SDC血浓度27％。地高辛总体、肾脏内外清除率分别减少30.1％、35.5％和35.4％。内生肌酐清除率减少30.16％。由于SDC升高的幅度较小,临床未见洋地黄毒副反应。
Fifteen patients with congestive heart failure complicating coronary heart disease were treated with captopril and digoxin. The results showed that captopril increased the serum digoxin concentration by reducing its renal and nonrenal clearance and decreased the creatinine clearance. These results seggest that the measurement of serum digoxin concentration should be necessary when such drug combinations are used.
出处
《天津医药》
CAS
1997年第3期145-146,共2页
Tianjin Medical Journal
