左旋硝基精氨酸诱导的高血压大鼠心肌肌浆膜Na-Ca交换功能的变化

CHANGES OF MYOCARDIAL SARCOLEMMAL VESICLE Na-Ca EXCHANGER IN HYPERTENSIVE RATS INDUCED BY L-NNA

目的：探讨高血压大鼠心肌肥大时心肌浆膜Na－Ca交换功能的变化。方法：采用同位素标记法。结果：心肌浆膜囊泡（SLV）对Na^+依赖的Ca^(2+)摄取与Ca2+浓度呈正相关。左旋硝基精氨酸（L－NNA）组大鼠明显低于对照组（P＜0．05或P＜0．01）。两组间Km值无明显变化，但最大摄取速率（Vmax）L－NNA组为对照组的74％。结论：L－NNA诱导的高血压动物心肌Na－Ca交换功能明显低于正常大鼠。

To investigate the changes of sarcolemmal vesicle Na-Ca exchanger of hypertensiverats induced by L-NNA. Methods: The isotope labeling method was used. Results: Calcium uptake ofmyocardial SLV of L-NNA induced hypertensive animal were significantly lower than that of the control(P＜0. 05 or P＜0．01)． Km of the two groups was not significantly different, while the Vmax of L-NNAgroup was only 74% of the control. Conclusion: The function of myocardial SLV Na-Ca exchanger ofL-NNA induced hypertensive rats is significantly lower than that of the normal rats.