慢性病毒性肝炎患者自身抗体及干扰素抗体的检测

AUTOANTIBODIES AND ANTI-INTERFERON ANTIBODY IN PATIENTS WITH CHRONIC VIRAL HEPATITIS

目的；分析自身抗体和干扰素抗体在慢性病毒性肝炎患者干扰素治疗时的检出情况及其与治疗效果的关系。方法：自身抗体的检测为间接免疫荧光法；应用酶免疫法测定干扰素抗体之总抗体。结果：（1）与正常人相比，患者自身抗体及干扰素抗体阳性率明显增高（P＜0．01），而且干扰素抗体在慢乙肝及慢丙肝患者中存在显著性差异（P＜0．05）；（2）自身抗体的存在与否和疗效无相关性（P＞0．05），干扰素抗体在治疗前已阳性和治疗后才转阳的患者，对干扰素治疗的反应可能有一定差异。结论：对于慢性病毒性肝炎患者来说，自身抗体及干扰素抗体的出现并不绝对意味着干扰素治疗效果的好坏。

To determine the autoantibodies and anti-interferon(IFN)antibody in chronic viralhepatitis patients treated with IFN and the relation between the antibodies and the curative effect ofIFN. Methods:Indirect immunofluorescence assay(IFA) for measuring the autoantibodies; Enzyme immunoassay (EIA ) for measuring the anti-IFN total antibody. Results: (1) Compared with normalgroups, the autoantibodies in patients increased significantly (P＜0．01 ); the anti-IFN antibody inchronic hepatitis B and chronic hepatitis C patients showed marked difference (P＜0. 05). (2)As to thecurative effect, the presence and absence of autoantibodies didn't have a distinct significance in patientstreated with α-IFN, but the patients with anti-IFN antibody be fore or after therapy might have a different response to α-IFN. Conclusion:The results suggested that the presence of autoantibodies and antiIFN antibody wasn't a contraindication to the use of interferon in patients with chronic viral hepatitis.