小型猪乳牙牙龈炎的研究

THE STUDY OF GINGIVITIS IN DECIDUOUS TEETH OF MINIPIGS

目的：检查小型猪的牙龈状况，以建立人牙龈炎的动物模型。方法：对8头小型猪进行了临床牙周检查、细菌学检查和龈沟液分析。结果：发现小型猪乳牙存在广泛性牙龈炎，牙龈炎症的程度与菌斑相关；龈沟液中天冬氨酸转氨酶（AST）水平和蛋白含量与人龈沟液的大致相同，蛋白含量的增多伴随AST水平的增高；龈下细菌中的牙龈叶琳菌和螺旋体计数与人牙龈炎大致类似，随着牙周袋深的增加球菌减小而螺旋体增多。结论：小型猪牙龈炎与人牙龈炎相似。

To investigate the spontaneously occurring gingivitis of minpigs as a model of human gingivitis. Methods: Eight minipigs were selected. Several clinical parameters, microbiology ofsubgingival plaques and biochemistry of gingival crevicular fluids(GCF) were studied. Results: Generalized marginal gingivitis was observed in all studied minipigs. The severity of gingival inflammation wassignificantly related to the score of plaque index(PLI). Analysis of subgingival plaques revealed that thecounting of porphyromanas gingivalis and the proportion of spirochetes were similar to human gingivitis. The proportion of cocci decreased with probing depth, while that of spirochetes increased. It wasalso found that the levels of protein and aspartate aminotransferase(AST)in GCF of minipigs were similar to human gingivitis. The protein level was correlated with AST level. Conclusion: This studydemonstrated that minipig could be used as a model in studies of human plaque-associated gingivitis.