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急性髓细胞白血病免疫表型与预后的关系 被引量:2

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摘要 目的分析急性髓细胞白血病免疫表型与预后的关系。方法用流式细胞术测定62例急性髓细胞白血病免疫表型。结果CD34+病例的完全缓解率明显低于CD34-组病例,差异有统计学意义(P<0.05);而难治病例发生率明显高于阴性组,差异有统计学意义(P<0.05)。Ly+AML的CR率与Ly-AML组相近,而Ly+AML组的难治病例发生率较Ly-AML明显增高,差异有统计学意义(P<0.05)。CD14+、CD38+、HLA-DR+各组与其阴性对照组的CR率、难治性病例发生率无统计学意义。结论CD34+AMLCR率低,难治病例发生率高,CD34是影响AML预后不良的因素。Ly+AML组难治病例发生率显著高于Ly-AML,预后不良。
出处 《内科》 2007年第5期740-742,共3页 Internal Medicine
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  • 1Lo-Coco F, Foa R. Diagnostic and prognostic advances in the immunophenotypic and genetic characterization of acute leukaemia[J]. Eur J Haematol, 1995, 55(1): 1-9.
  • 2Bene MC, Castoldi G, Knapp W, et al. Proposals for the immunological classification of acute leukemias. Europoan Group for the Immunological Characterization of Lcukemias (EGIL) [ J ]. Leukemia, 1995, 9(10): 1783-6.
  • 3Jennings CD, Foon KA. Recent advances in flow cytometry:, application to the diagnosis of hematologic malignancy[J]. Blood, 1997,90(8): 2863-92.
  • 4Khalidi HS, Medeiros LJ, Chang KL, et al. The immunophenotype of adult acute myeloid leukemia: high frequency of lymphoid antigen expression and comparison of immunophenotype, French-American-British classification, and katyotypic abnormalities[J].Am J Clin Pathol, 1998, 109(2): 211-20.
  • 5Casasnovas RO, Slimane FK, Garand R, et al. Immunological classification of acute myeloblastic leukemias: relevance to patient outcome[J]. Leukemia, 2003, 17(3): 515-27.
  • 6Baer MR, Stewart CC, Lawrence D, et aL Expression of the neural cell adhesion molecule CD56 is associated with short remission duration and survival in acute myeloid leukemia with t (8;21)(q22;q22)[J]. Blood, 1997, 90(4): 1643-8.
  • 7Suzuki R, Nakamura S. Malignancies of natural killer (NK) cell precursor: myeloid/NK cell precursor acute leukemia and blastic NK cell lymphoma/leukemia[J]. Leuk Res, 1999, 23(7): 615-24.
  • 8Raspadori D, Damiani D, Lenoci M, et al. CD56 antigonic expression in acute myeloid leukemia identifies patients with poor clinical prognosis[J]. Leukemia, 2001, 15(8): 1161-4.
  • 9Preti HA, Huh YO, O'Brien SM, et al. Myeloid markets in adult acute lymphocytic leukemia. Correlations with patient and disease characteristics and with prognosis[J ]. Cancer, 1995, 76(9): 1564-70.
  • 10Putti MC, Rondelli R, Cocito MG, et al. Expression of mycloid markers lacks prognostic impact in children treated for acute lymphoblastic leukemia: Italian experience in AIEOP-ALL 88-91 studies[J]. Blood, 1998, 92(3): 795-801.

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  • 1黄欣.流式细胞术用于急性白血病免疫分型现状[J].检验医学与临床,2006,3(4):160-162. 被引量:12
  • 2刘贵建.急性白血病的MICM分型[J].中华检验医学杂志,2004,27(6):398-400. 被引量:12
  • 3宋建新,苏敏,张芹,方蒡,甸自金,欧阳红梅,陈斌,台虹.282例急性白血病流式细胞术免疫分型的特点分析[J].现代检验医学杂志,2005,20(1):35-38. 被引量:11
  • 4王兴兵,郑金娥,谷俊侠,姚军霞,杨晶,刘隽,李小青,贺艳丽,喻竞明,魏君,刘仲萍,黄士昂.成人急性髓细胞性白血病免疫表型与细胞遗传学及临床特征的关系[J].癌症,2005,24(6):667-671. 被引量:16
  • 5Gazitt Y. Homing and mohilizalion of hematopoieflic stem Cells hematopoitic cancer cells are mirror image processes Utilizing similar signaling pathways and occurring concurrently:circulation cancer cells constitutean ideal taget with chemotherapy and antlilineage specific antibodies [ J ]. Leukemia,2004,18 ( 1 ) : 1.
  • 6许文荣,王建中.临床血液学与检验[M].4版.北京:人民卫生出版社,2008:259.
  • 7张之南.血液学诊断及疗效标准[M].2版.北京:科学出版社,1998:96.
  • 8BENE M C,CASTOLDI G,KNAPP W’et al. Propos-als for the immunological classification of acute leuke-mia[J]. Leukemia, 1995,9:1783 — 1786.
  • 9LEGRAND O,PERROT J Y,BAUDARD M,et al.The immunophentype of 177 adults with acute mye-loid leukemia; proposal of a prognostic score [J].Blood,2000,96:876-877.
  • 10KITA K, MIWA H,NAKASE K,et al. Clinical im-portance of CD7 expression in acute myelocytic leuke-imia[J]. Blood, 1993,81:2399 — 2405.

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