反复摄取烟碱对脑肌醇含量的影响

EFFECTS OF REPEATED NICOTINE UPTAKE ON BRAIN INOSITOL LEVELS

急性实验中，间隔５ｍｉｎ反复注射烟碱０．５，１．０，１．０，２．０，２．０ｍｇ／ｋｇｉｐ，３０ｍｉｎ后大鼠大脑皮层及海马中肌醇含量升高，但纹状体中肌醇含量无显著变化；相同条件下，氯化锂１０ｍｍｏｌ／ｋｇｉｐ３０ｍｉｎ后大脑皮层和海马中肌醇含量显著降低；慢性实验中，烟碱２．０－１０．０ｍｇ／ｋｇｓｃｂｉｄ１４ｄ后，大鼠大脑皮层中肌醇含量显著增高；烟碱２．６９－１１．５３ｍｇ／ｋｇ／ｄｐｏ６４ｄ后，大鼠大脑皮层中肌醇含量也显著增高。表明烟碱的作用不同于氯化锂，反复给予烟碱可使大鼠大脑皮层中肌醇含量增加。

In the acute experiments,30 minutes after nicotine was intraperitoneally injected at the doses of 0.5, 1.0, 1.0, 2.0, 2.0mg/kg with 5 min interval,the inositol levels were increased in rats cerebral cortex and hippocampus rather than striatum.While the inositol level was decreased in rat cerebral cortex 30 minutes after lithium chloride was given at the dose of 10mmol/kg.In the chronic experiments,after nicotine at the doses of 2.0-5.0mg/kg was subcutaneouly injected twice a day for 14 days the inositol level was increased in rat cerebral cortex.In other experiments,nicotine was orally given at the dosese of 2.69,6.26,11.53mg/kg·d for 64 days,the inositol level of rat cerebral cortex was also increased.These indicated that the effects of nicotine on inositol level of rat brain are different from those of lithium chloride,the inositol level of rat cerebral cortex can be increased by repeated administration of nicotine.