重组人干扰素α2b阴道泡腾片抗豚鼠单纯疱疹病毒性阴道炎的疗效

Curative Effect of Recombinant Human Interferon α2b Vaginal Effervescent Tablet on Vaginitis Caused by Herpes Simplex Virus Type 2(HSV-2) in Guinea Pigs

目的观察重组人干扰素α2b阴道泡腾片对单纯疱疹病毒性阴道炎动物模型的疗效。方法采用单纯疱疹病毒感染建立豚鼠实验性阴道炎模型,并分别用重组人干扰素α2b阴道泡腾片600、3 000和15 000 IU/只进行治疗。以阿昔洛韦(无环鸟苷)和干扰素α2b栓剂15 000 IU/只作为对照。对治疗前后豚鼠阴道外观及组织切片进行评分。结果应用重组人干扰素α2b阴道泡腾片对豚鼠实验性单纯疱疹病毒性阴道炎进行治疗后,豚鼠阴道外观病变与组织切片病变评分均显著降低,其中15 000 IU/只效果最好。同样剂量的α2b泡腾片药效优于栓剂。结论重组人干扰素α2b阴道泡腾片对实验性单纯疱疹病毒性阴道炎有明显的疗效。

Objective To observe the curative effect of recombinant human interferon （rhlFN） α2b vaginal effervescent tablet on vaginitis caused by herpes simplex virus type 2 （HSV-2） in guinea pig model. Methods Establish experimental guinea pig model of vaginitis by infection with HSV-2 and treat with rhlFN α2b vaginal effervescent tablet at dosages of 600,3000 and 15 000 IU respectively,using acyclovir （0. 1 g） and rhlFN α2b suppository 15 000 IU as controls. Score the pathological changes of appearance and tissue sections of viginae before and after treatment. Results The scores for pathological changes of appearance and tissue sections of viginae after treatment with rhlFN α2b vaginal effervescent tablet were significantly lower than those after treatment with acyclovir or rhlFN α2b suppository. Compared with that at dosages of 600 and 3000 IU, the rhlFN α2b vaginal effervescent tablet at a dosage of 15 000 IU was more effective in decreasing the scores. At the same dosage,rhlFN α2b vaginal effervescent tablet showed good curative effect as compared with rhlFN α2b suppository. Conclusion rhlFN α2b vaginal effervescent tablet showed significant curative effect on experimental vaginitis caused by HSV-2.