国产水痘减毒活疫苗在免疫损害病人中的应用

Application of Domestic Live Attenuated Varicella Vaccine in Immunocompromised Patients

目的观察国产Oka株水痘减毒活疫苗在急性白血病、实体肿瘤和接受免疫抑制剂治疗的免疫损害病人中的反应原性和抗体应答。方法国产Oka株水痘减毒活疫苗接种于3种免疫损害病人,用ELISA法检测免疫前和免疫后抗体水平,并观察副反应情况。结果接种疫苗的3种病人均无异常反应发生,仅有少数病人在观察期内有中强程度发热,其中以实体肿瘤病人略多。3种病人接种前多数抗体阳性,经疫苗免疫后,抗体滴度均有不同程度上升,正在使用免疫抑制剂者抗体滴度上升不明显。结论免疫损害病人接种国产水痘减毒活疫苗是安全有效的。

Objective To observe the reactogenicity and antibody response of domestic live attenuated varicella vaccine prepared with Oka strain in the patients with acute leukemia or solid tumors or receiving immunosuppressants. Methods Immunize the above-mentioned immunocompromised patients with domestic live attenuated varicella vaccine prepared with Oka strain, determine the antibody levels before and after immunization and observe the adverse reactions. Results No abnormal reactions were observed in all the patients. Moderate or severe fever were observed in a few patients ,most of whom were those with solid tumors. Most of the patients were positive for varicella antibody before immunization, and their antibody titers increased at various degrees after immunization. However,the antibody titers of patients treated with immunosuppressants showed no significant increase. Conclusion Domestic live attenuated varicella vaccine was safe and effective in immunocompromised patients.