丙泊酚复合瑞芬太尼用于人工流产术的麻醉

Anesthesia with Propofol combined with remifentanil in artificial abortion

目的:观察丙泊酚复合瑞芬太尼用于人工流产术的麻醉效果及对呼吸、循环系统的影响。方法:选择40例拟行人工流产术且无相关禁忌证的患者,ASAⅠ~Ⅱ级,年龄18~32岁,体重43kg^62kg。随机分为两组,丙泊酚复合瑞芬太尼组(R组)和丙泊酚组(P组),每组各20例。两组手术方法相同,年龄、体重和人流时间均无差异(P>0.05)。R组瑞芬太尼静脉滴注剂量为0.75μg/kg,丙泊酚静脉滴注剂量为2mg/kg,P组丙泊酚静脉滴注剂量为3mg/kg。两组待麻醉满意后开始行人工流产术,同时观察诱导前、诱导后、手术结束时血压(Bp)、心率(HR)、血氧饱和度(SpO2)以及苏醒时间,并对麻醉效果进行分析评价。结果:R组诱导和苏醒时间明显短于P组(P<0.05);P组诱导后2min时Bp下降、HR减慢、SpO2降低比R组明显(P<0.05);R组麻醉效果明显优于P组(P<0.05)。结论:丙泊酚复合瑞芬太尼用于人工流产,麻醉镇痛效果确切,用药量小,起效快,呼吸、循环抑制较轻,患者术后苏醒快,此方法优于单纯用丙泊酚麻醉治疗者。

Objective To investigate the anesthesia effect of Propofol combined with remffentanil in artificial abortion and the possible impact on respiratory system and circulation system. Method Forty patients undergoing artificial abortion （ ASA Ⅰ - Ⅱ, age： 18 - 32 years, weight： 43 -62kg） were allocated into two groups randomly as Propofol combined with remifentanil group （group R） and Propofol group （group P）, with 20 patients in each group. Group R was administered Propofol （2mg/kg, i. v. ） combined with remlfentanil （0.75μg/kg, i.v. ） and group P was administered Propofol （3mg/kg, i. v. ）. The two groups received the same operation with the same method, and there was no significant meaning of age, weight and abortion time between the two groups （ P 〉 0. 05 ）. Blood pressure （ BP）, heart rate （ HR）, saturation of blood oxygen （ SpO2 ）, awake time and anesthesia effect were observed pre - anesthesia, post - anesthesia and end of anesthesia, respectively. Results Induction time and awake time of group R were significantly shorter than that of group P （P 〈 0. 05） ; The decrease of BP, HR and SpO2 in group P 2rain after anesthesia were more obvious than that of group R （P 〈 0. 05）. The anesthesia effect in group R was better than that of group P （ P 〈 0. 05）. Conclusion Anesthesia with Propofol plus remifentanil in artificial abortion has a definite effect of analgesia. Little dosage, working and waking fast, little inhibition in respiritory and circulation system make it better than anesthesia with Propofol alone.