Ⅱ型胶原在颞下颌关节骨关节病髁突软骨的表达

Expression of collagen type Ⅱ in condylar cartilage of temporomandibular joint osteoarthrosis

目的:观察Ⅱ型胶原(CⅡ)在颞下颌关节骨关节病(TMJOA)髁突软骨的变化特征,探讨CⅡ在TMJOA髁突软骨破坏中的作用。方法:采用部分切除关节盘的方法诱发TMJOA动物模型,应用免疫组织化学的方法检测CⅡ在不同病变时期髁突软骨的表达。结果:关节盘部分切除后,CⅡ在不同病变时期髁突软骨的表达均有所增强。结论:CⅡ可能在骨关节病髁突软骨的破坏过程中起代偿作用。

Objective： To observe the distribution of collagen type Ⅱ （C Ⅱ ）in condylar cartilage of temporomandibular joint osteoarthrosis （TMJOA） and discuss the role of C Ⅱ in the degeneration of condylar cartilage. Methods： Rats TMJOA animal models were established following surgically temporomandibular joint disc perforated, expression of C Ⅱ in condylar cartilage of different stages were examined with immunohistochemical staining. Results： After temporomandibular joint disc perforated, expression of C Ⅱ in condylar cartilage of different stages increased. Conclusion： C Ⅱ may play a repairing role in the progression of TMJOA.